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XB-ART-26872
FEBS Lett 1989 Mar 13;2451-2:215-8.
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Particular processing of pro-opiomelanocortin in Xenopus laevis intermediate pituitary. Sequencing of alpha- and beta-melanocyte-stimulating hormones.

Rouillé Y , Michel G , Chauvet MT , Chauvet J , Acher R .


Abstract
alpha- and beta-melanocyte-stimulating hormones (alpha-MSH and beta-MSH) have been isolated from Xenopus laevis neurointermediate pituitary and microsequenced. Intracellular alpha-MSH is not N-acetylated after proteolytic processing of pro-opiomelanocortin in contrast to mammalian alpha-MSHs. There is a high preservation of the melanotropic amino acid sequence common to all MSHs although in Xenopus beta-MSH a histidine residue replaces the glutamic acid residue found in position 8 of mammalian beta-MSHs.

PubMed ID: 2564347
Article link: FEBS Lett


Species referenced: Xenopus laevis
Genes referenced: pomc