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Proc R Soc Lond B Biol Sci 1982 Nov 22;2161205:509-15. doi: 10.1098/rspb.1982.0089.
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Synthesis of chick brain GABA receptors by frog oocytes.

Miledi R , Parker I , Sumikawa K .

Poly(A)-mRNA, extracted from the optic lobe of chick embryos, directs the synthesis of gamma-aminobutyric acid (GABA) receptors in Xenopus laevis oocytes. The receptors are inserted into the oocyte membrane, where they form receptor--channel complexes. When activated by GABA, and related agonists, the chick brain receptors open membrane channels that are permeable to chloride ions. Thus, Xenopus oocytes provide a novel and useful approach to the study of brain receptors.

PubMed ID: 6129641
Article link: Proc R Soc Lond B Biol Sci