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XB-ART-27151
EMBO J 1988 Dec 01;712:3873-9. doi: 10.1002/j.1460-2075.1988.tb03273.x.
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The Xenopus laevis mitochondrial protein mtDBP-C cooperatively folds the DNA in vitro.

Mignotte B , Delain E , Rickwood D , Barat-Gueride M .


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The binding of the Xenopus laevis mitochondrial protein mtDBP-C to DNA was studied by equilibrium density banding, agarose gel electrophoresis and electron microscopy. The results obtained show that the mtDBP-C binds cooperatively to DNA irrespective of whether the DNA is supercoiled, relaxed or linear and it induces the formation of superhelical turns locally leading to the formation of a highly folded structure. It appears that this protein could be involved in the compaction of DNA in the mitochondrial nucleoid.

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Species referenced: Xenopus laevis

References [+] :
Barat, Characterization of DNA-protein complexes from the mitochondria of Xenopus laevis oocytes. 1985, Pubmed, Xenbase