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XB-ART-5570
Nat Cell Biol 2003 Mar 01;53:179-82. doi: 10.1038/ncb0303-179.
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Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

Bienz M , Clevers H .


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Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is beta-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/beta-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin.

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