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J Neurosci 1999 Nov 01;1921:9364-73.
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Neuralization of the Xenopus embryo by inhibition of p300/ CREB-binding protein function.

Kato Y , Shi Y , He X .

p300/ CREB-binding protein (CBP) is a transcriptional coactivator for a plethora of transcription factors and plays critical roles in signal transduction pathways. We report that the inhibition of p300/CBP function in the Xenopus embryo abolishes non-neural tissue formation and, strikingly, initiates neural induction and primary neurogenesis in the entire embryo. The observed neuralization is achieved in the absence of anterior or posterior gene expression, suggesting that neural fate activation and anterior patterning may represent distinct molecular events. We further demonstrate that the neuralizing and anteriorizing activities of chordin and noggin are separable properties of these neural inducers. This study reveals that all embryonic cells possess intrinsic neuralizing capability and that p300/CBP function is essential for embryonic germ layer formation and neural fate suppression during vertebrate embryogenesis.

PubMed ID: 10531441
PMC ID: PMC6782909
Article link: J Neurosci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: a2m acvr1 celf3 chrd creb1 crebbp egr2 ep300 gli1 gsc hoxb9 irx2 irx3 krt12.4 mix1 mixer mst1 msx1 ncam1 neurog1 nodal3.2 nog otx2 sia1 sox17a sox3 tbxt tubb2b ventx1 zic1 zic2 zic3

Article Images: [+] show captions
References [+] :
Aberger, The Xenopus homologue of hepatocyte growth factor-like protein is specifically expressed in the presumptive neural plate during gastrulation. 1996, Pubmed, Xenbase