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XB-ART-19825
Nucleic Acids Res 1995 Apr 25;238:1396-7.
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Xenopus egg lysates repair heat-generated DNA nicks with an average patch size of 36 nucleotides.

Höfferer L , Winterhalter KH , Althaus FR .


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Base excision repair (BER) is an essential DNA repair pathway since it processes spontaneous (endogenous) DNA damage such as abasic sites, oxidized and alkylated bases, as well as mismatches arising from deamination of cytosine and 5-methylcytosine. Some of these lesions are repaired by the exchange of a single deoxynucleotide [Dianov, G. et al. (1992) Mol. Cell. Biol. 12, 1605-1612; Wiebauer, K. and Jiricny, J. (1990) Proc. Natl. Acad. Sci. USA, 87, 5842-5845] or a few deoxynucleotides [Matsumoto, Y. et al. (1994) Mol. Cell. Biol., 14 6187-6197]. Here we report that DNA single strand breaks induced by hyperthermic conditions are repaired with an average patch size of approximately 36 nt in Xenopus laevis egg lysates.

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Species referenced: Xenopus laevis
Genes referenced: tbx2

References [+] :
Almouzni, Assembly of spaced chromatin promoted by DNA synthesis in extracts from Xenopus eggs. 1988, Pubmed, Xenbase