Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-8348
Neuroreport 2001 Oct 08;1214:3121-5. doi: 10.1097/00001756-200110080-00028.
Show Gene links Show Anatomy links

Lead inhibition of NMDA channels in native and recombinant receptors.

Gavazzo P , Gazzoli A , Mazzolini M , Marchetti C .


???displayArticle.abstract???
NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycine affinity as well as sensitivity to ifenprodil change significantly with the days in vitro, indicating a reduction of NR2B subunit expression. Pb2+ blocked NMDA current with IC50 approximately 4 microM and this effect decreased significantly during the second week in vitro. In Xenopus laevis oocytes expressing recombinant NR1-NR2A, NR1-NR2B or NR1-NR2C receptors, Pb2+ inhibited glutamate-activated currents with IC50 of 3.3, 2.5 and 4.7 microM respectively. These data indicate that Pb2+ action is dependent on subunit composition and suggest that down-regulation of the NR2B subunit is correlated to a diminished sensitivity to Pb2+ inhibition.

???displayArticle.pubmedLink??? 11568649
???displayArticle.link??? Neuroreport


Species referenced: Xenopus laevis
Genes referenced: grin1 grin2a grin2b grin2c