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XB-ART-13762
Cell 1998 Dec 11;956:779-91. doi: 10.1016/s0092-8674(00)81701-8.
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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

Tsukazaki T , Chiang TA , Davison AF , Attisano L , Wrana JL .


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Smads transmit signals from transmembrane ser/thr kinase receptors to the nucleus. We now identify SARA (for Smad anchor for receptor activation), a FYVE domain protein that interacts directly with Smad2 and Smad3. SARA functions to recruit Smad2 to the TGFbeta receptor by controlling the subcellular localization of Smad2 and by interacting with the TGFbeta receptor complex. Phosphorylation of Smad2 induces dissociation from SARA with concomitant formation of Smad2/Smad4 complexes and nuclear translocation. Furthermore, mutations in SARA that cause mislocalization of Smad2 inhibit TGFbeta-dependent transcriptional responses, indicating that the regulation of Smad localization is important for TGFbeta signaling. These results thus define SARA as a component of the TGFbeta pathway that brings the Smad substrate to the receptor.

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Species referenced: Xenopus
Genes referenced: smad10 smad2 smad3 smad4 tgfb1 zfyve9