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XB-ART-25771
Mol Cell Biol 1990 Jul 01;107:3810-2. doi: 10.1128/mcb.10.7.3810-3812.1990.
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rUBF, an RNA polymerase I transcription factor from rats, produces DNase I footprints identical to those produced by xUBF, its homolog from frogs.

Pikaard CS , Smith SD , Reeder RH , Rothblum L .


Abstract
Rat cells contain a DNA-binding polymerase I transcription factor, rUBF, with properties similar to UBF homologs that have been purified from both human (hUBF) and frog (xUBF) cells. In this note we report the affinity purification of rUBF to apparent homogeneity and show that UBFs from both rat and frog have identical footprinting characteristics on templates from either species. Furthermore, xUBF was able to stimulate transcription from rat RNA polymerase I promoters in a partially fractionated rat extract that was UBF dependent. These results strengthen the conclusion that all vertebrate cells contain a UBF homolog whose DNA-binding specificity and function have been strongly conserved.

PubMed ID: 2355924
PMC ID: PMC360842
Article link: Mol Cell Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: ubtf

References [+] :
Bell, Molecular mechanisms governing species-specific transcription of ribosomal RNA. 1989, Pubmed, Xenbase