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Res Commun Chem Pathol Pharmacol 1992 Jul 01;771:3-16.
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pNiXa, a Ni(2+)-binding protein in Xenopus oocytes and embryos, shows identity to Ep45, an estrogen-regulated hepatic serpin.

Beck BL , Henjum DC , Antonijczuk K , Zaharia O , Korza G , Ozols J , Hopfer SM , Barber AM , Sunderman FW .

A Ni(2+)-binding protein (pNiXa, 45 kD, pI 8.5) discovered in Xenopus embryos, was isolated from oocytes. Based on amino acid sequences, pNiXa belongs to the serpin superfamily and shows identity to the cDNA sequence of Ep45, an estrogen-regulated hepatic serpin that contains an (HX)n-motif found in eukaryotic transcription factors. Nondenatured pNiXa, purified by Ni-affinity chromatography, inhibited bovine alpha-chymotrypsin. The presence of pNiXa in embryos when they are susceptible to Ni2+, the high avidity of pNiXa for Ni2+, and the (HX)n-motif point to pNiXa as a molecular target of Ni(2+)-teratogenesis.

PubMed ID: 1439178

Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: serpina6