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XB-ART-27235
Dev Biol 1988 Nov 01;4643:243-6.
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Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain.

Horikoshi T , Asanuma A , Yanagisawa K , Goto S .


Abstract
The modulatory action of taurine on the glycine response was investigated in Xenopus oocytes injected with messenger RNA from mouse brainstem under voltage-clamped condition. Taurine competitively inhibited the glycine response in a dose-dependent manner. This inhibition was insensitive to bicuculline and intracellularly injected EGTA. The results suggest that taurine could directly modulate glycinergic neurotransmission in the central nervous system.

PubMed ID: 2850085