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XB-ART-32432
Dev Biol 1976 Sep 01;522:318-22.
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Inhibition of oocyte maturation by theophylline: possible mechanism of action.

O'Connor CM , Smith LD .


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Theophylline, a competitive inhibitor of cAMP phosphodiesterase, inhibits the maturation of oocytes previously exposed to progesterone. Cyclic AMP levels remain constant both during normal maturation and in response to theophylline, even though the latter effectively inhibits phosphodiesterase activity in the oocyte. Thus, the inhibition is not attributable to elevated cAMP levels. Rather, we suggest that theophylline may exert its inhibitory effects on maturation either by reducing rates of protein synthesis or possibly through effects at the oocyte surface.

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Genes referenced: camp