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Nat Neurosci
2011 May 01;145:548-50. doi: 10.1038/nn.2772.
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Sensory modality-specific homeostatic plasticity in the developing optic tectum.
Deeg KE
,
Aizenman CD
.
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We found a previously unknown form of homeostatic synaptic plasticity in multisensory neurons in the optic tectum of Xenopus laevis tadpoles. Individual tectal neurons are known to receive converging inputs from multiple sensory modalities. We observed that long-term alterations in either visual or mechanosensory activity in vivo resulted in homeostatic changes specific to each sensory modality. In contrast with typical forms of homeostatic synaptic plasticity, such as synaptic scaling, we found that this type of plasticity occurred in a pathway-specific manner that is more reminiscent of hebbian-type plasticity.
Figure 2. Modality-specific changes in aEPSC amplitude after various sensory manipulations(A) aEPSCs evoked by visual or hindbrain stimulation after 48 hours of visual deprivation (left), enhanced mechanosensory stimulation (middle) or enhanced mechanosensory stimulation in the presence of inhibitory blockers (right). (B) Comparison of hindbrain and visual stimulation after various experimental conditions. Symbols next to paired data represent average values and error bars are SEM. (C) Scatterplot of aEPSC amplitude evoked by each pathway after various experimental conditions. (E) Cumulative probability distribution of aEPSC amplitudes from both pathways superimposed with spontaneous EPSC (sEPSC) amplitudes after various experimental conditions. Stars indicate p<0.05.
Figure 3. Summary of synaptic changes after in vivo sensory manipulations(A) Averaged data comparing aEPSC amplitude evoked by visual and mechanosensory pathways under various conditions. Notice modality specific changes. (B) Cumulative probability plots of sEPSC amplitudes from different experimental groups. Inset shows average sEPSC amplitudes across conditions. Error bars are SEM, stars indicate p<0.05. For direct comparisons see Sup. Fig. 5.
Deeg,
Development of multisensory convergence in the Xenopus optic tectum.
2009, Pubmed,
Xenbase
Deeg,
Development of multisensory convergence in the Xenopus optic tectum.
2009,
Pubmed
,
Xenbase
Desai,
Critical periods for experience-dependent synaptic scaling in visual cortex.
2002,
Pubmed
Goel,
Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience.
2006,
Pubmed
Hiramoto,
Convergence of multisensory inputs in Xenopus tadpole tectum.
2009,
Pubmed
,
Xenbase
Kim,
Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
2008,
Pubmed
Kuczewski,
Activity-dependent dendritic release of BDNF and biological consequences.
2009,
Pubmed
Pratt,
Homeostatic regulation of intrinsic excitability and synaptic transmission in a developing visual circuit.
2007,
Pubmed
,
Xenbase
Pratt,
Development and spike timing-dependent plasticity of recurrent excitation in the Xenopus optic tectum.
2008,
Pubmed
,
Xenbase
Rutherford,
BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses.
1998,
Pubmed
Steward,
Compartmentalized synthesis and degradation of proteins in neurons.
2003,
Pubmed
Turrigiano,
Hebb and homeostasis in neuronal plasticity.
2000,
Pubmed
Turrigiano,
Activity-dependent scaling of quantal amplitude in neocortical neurons.
1998,
Pubmed
Tyler,
Experience-dependent modification of primary sensory synapses in the mammalian olfactory bulb.
2007,
Pubmed
Xu-Friedman,
Probing fundamental aspects of synaptic transmission with strontium.
2000,
Pubmed
