XB-ART-37189
Virol J
2007 Oct 18;4:100. doi: 10.1186/1743-422X-4-100.
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Cytopathic mechanisms of HIV-1.
Costin JM
.
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The human immunodeficiency virus type 1 (HIV-1) has been intensely investigated since its discovery in 1983 as the cause of acquired immune deficiency syndrome (AIDS). With relatively few proteins made by the virus, it is able to accomplish many tasks, with each protein serving multiple functions. The Envelope glycoprotein, composed of the two noncovalently linked subunits, SU (surface glycoprotein) and TM (transmembrane glycoprotein) is largely responsible for host cell recognition and entry respectively. While the roles of the N-terminal residues of TM is well established as a fusion pore and anchor for Env into cell membranes, the role of the C-terminus of the protein is not well understood and is fiercely debated. This review gathers information on TM in an attempt to shed some light on the functional regions of this protein.
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Species referenced: Xenopus
Genes referenced: tbx2
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References [+] :
Agirre,
Viroporin-mediated membrane permeabilization. Pore formation by nonstructural poliovirus 2B protein.
2002, Pubmed
Agirre, Viroporin-mediated membrane permeabilization. Pore formation by nonstructural poliovirus 2B protein. 2002, Pubmed
Aldabe, Membrane permeabilization by poliovirus proteins 2B and 2BC. 1996, Pubmed
Alimonti, Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. 2003, Pubmed
Andreu, N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties. 1985, Pubmed
Arnaout, A simple relationship between viral load and survival time in HIV-1 infection. 1999, Pubmed
Bannert, The level of CD4 expression limits infection of primary rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses. 2000, Pubmed
Barré-Sinoussi, Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). 1983, Pubmed
Basañez, HIV and apoptosis death and the mitochondrion. 2001, Pubmed
Bashford, Common action of certain viruses, toxins, and activated complement: pore formation and its prevention by extracellular Ca2+. 1984, Pubmed
Beary, Interruption of T-cell signal transduction by lentivirus lytic peptides from HIV-1 transmembrane protein. 1998, Pubmed
Becker, Chemical synthesis and single channel properties of tetrameric and pentameric TASPs (template-assembled synthetic proteins) derived from the transmembrane domain of HIV virus protein u (Vpu). 2004, Pubmed
Berkowitz, Magainins: a new family of membrane-active host defense peptides. 1990, Pubmed , Xenbase
Bleul, The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. 1997, Pubmed
Bour, The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release. 2003, Pubmed
Bowman, Crystal structure of the oligomerization domain of NSP4 from rotavirus reveals a core metal-binding site. 2000, Pubmed
Boya, Viral proteins targeting mitochondria: controlling cell death. 2004, Pubmed
Bubien, HIV-gp120 activates large-conductance apamin-sensitive potassium channels in rat astrocytes. 1995, Pubmed
Bui, Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins. 1996, Pubmed
Carbonari, Death of bystander cells by a novel pathway involving early mitochondrial damage in human immunodeficiency virus-related lymphadenopathy. 1997, Pubmed
Carrasco, Modification of membrane permeability by animal viruses. 1995, Pubmed
Carrère-Kremer, Subcellular localization and topology of the p7 polypeptide of hepatitis C virus. 2002, Pubmed
Castrillo, Effects of extracellular cations on translation in poliovirus-infected cells. 1987, Pubmed
Chen, Cellular membrane-binding ability of the C-terminal cytoplasmic domain of human immunodeficiency virus type 1 envelope transmembrane protein gp41. 2001, Pubmed
Chen, Synthetic magainin analogues with improved antimicrobial activity. 1988, Pubmed , Xenbase
Chernomordik, An amphipathic peptide from the C-terminal region of the human immunodeficiency virus envelope glycoprotein causes pore formation in membranes. 1994, Pubmed
Choi, Role of potassium in human immunodeficiency virus production and cytopathic effects. 1998, Pubmed
Ciampor, The ion channels coded by viruses. 2003, Pubmed
Cloyd, Perturbation of host-cell membrane is a primary mechanism of HIV cytopathology. 1991, Pubmed
Coady, Effects of Vpu expression on Xenopus oocyte membrane conductance. 1998, Pubmed , Xenbase
Cocchi, The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. 1996, Pubmed
Coffin, HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. 1995, Pubmed
Comardelle, A synthetic peptide corresponding to the carboxy terminus of human immunodeficiency virus type 1 transmembrane glycoprotein induces alterations in the ionic permeability of Xenopus laevis oocytes. 1997, Pubmed , Xenbase
Cruciani, Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes. 1992, Pubmed , Xenbase
Cuconati, A protein linkage map of the P2 nonstructural proteins of poliovirus. 1998, Pubmed
Daar, Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. 1991, Pubmed
Dalgleish, The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. , Pubmed
Danthi, Genome delivery and ion channel properties are altered in VP4 mutants of poliovirus. 2003, Pubmed
Deng, Identification of a major co-receptor for primary isolates of HIV-1. 1996, Pubmed
Doms, The plasma membrane as a combat zone in the HIV battlefield. 2000, Pubmed
Douek, Disrupting T-cell homeostasis: how HIV-1 infection causes disease. 2003, Pubmed
Duff, The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayers. 1992, Pubmed
Eisenberg, The most highly amphiphilic alpha-helices include two amino acid segments in human immunodeficiency virus glycoprotein 41. 1990, Pubmed
Estes, A viral enterotoxin. A new mechanism of virus-induced pathogenesis. 1999, Pubmed
Ewart, The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels. 1996, Pubmed
Fahey, Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. 1998, Pubmed
Fattal, Pore-forming peptides induce rapid phospholipid flip-flop in membranes. 1994, Pubmed
Fermin, Membrane alterations linked to early interactions of HIV with the cell surface. 1992, Pubmed
Finkel, Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells? 1994, Pubmed
Finzi, Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. 1997, Pubmed
Fischer, Amantadine blocks channel activity of the transmembrane segment of the NB protein from influenza B. 2001, Pubmed
Fischer, Viral ion channels: structure and function. 2002, Pubmed
Fischer, Transmembrane domains of viral ion channel proteins: a molecular dynamics simulation study. 2000, Pubmed
Fischer, Transmembrane peptide NB of influenza B: a simulation, structure, and conductance study. 2000, Pubmed
Fisher, Infectious mutants of HTLV-III with changes in the 3' region and markedly reduced cytopathic effects. 1986, Pubmed
Foster, Survey of virally mediated permeability changes. 1980, Pubmed
Freed, Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix. 1995, Pubmed
Fujii, A molecular model for membrane fusion based on solution studies of an amphiphilic peptide from HIV gp41. 1992, Pubmed
Gabuzda, Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins. 1992, Pubmed
Gallo, Historical essay. The early years of HIV/AIDS. 2002, Pubmed
Gallo, Historical essay. Prospects for the future. 2002, Pubmed
Gallo, The discovery of HIV as the cause of AIDS. 2003, Pubmed
Gallo, Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. 1984, Pubmed
Garry, Na+ and K+ concentrations and the regulation of protein synthesis in Sindbis virus-infected chick cells. 1979, Pubmed
Garry, Differential effects of ouabain on host- and sindbis virus-specified protein synthesis. 1979, Pubmed
Garry, Membrane-mediated alterations of intracellular Na+ and K+ in lytic-virus-infected and retrovirus-transformed cells. 1982, Pubmed
Garry, Unexpected similarity between the carboxyl termini of lentivirus and pestivirus envelope glycoproteins. 2003, Pubmed
Garry, Sindbis virus-induced inhibition of protein synthesis is partially reversed by medium containing an elevated potassium concentration. 1994, Pubmed
Garry, Cell surface effects of human immunodeficiency virus. 1988, Pubmed
Garry, Alteration of intracellular monovalent cation concentrations by a poliovirus mutant which encodes a defective 2A protease. 1989, Pubmed
Garry, Potential mechanisms for the cytopathic properties of HIV. 1989, Pubmed
Gatti, Inhibition of HIV type 1 production by hygromycin B. 1998, Pubmed
Gawrisch, Interaction of peptide fragment 828-848 of the envelope glycoprotein of human immunodeficiency virus type I with lipid bilayers. 1993, Pubmed
Geijtenbeek, DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. 2000, Pubmed
Golantsova, Discrete domains within the rotavirus VP5* direct peripheral membrane association and membrane permeability. 2004, Pubmed
Gonzalez, Viroporins. 2003, Pubmed
González, Human immunodeficiency virus type 1 VPU protein affects Sindbis virus glycoprotein processing and enhances membrane permeabilization. 2001, Pubmed
Gottlieb, Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. 1981, Pubmed
Grewe, HIV: early virus-cell interactions. 1990, Pubmed
Griffin, The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. 2003, Pubmed
Griffin, A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria. 2004, Pubmed
Haffar, Topogenic analysis of the human immunodeficiency virus type 1 envelope glycoprotein, gp160, in microsomal membranes. 1988, Pubmed
Haffar, The cytoplasmic tail of HIV-1 gp160 contains regions that associate with cellular membranes. 1991, Pubmed
Halestrap, The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. 2003, Pubmed
Harada, E2-p7 region of the bovine viral diarrhea virus polyprotein: processing and functional studies. 2000, Pubmed
Hay, The molecular basis of the specific anti-influenza action of amantadine. 1985, Pubmed
Helenius, Unpacking the incoming influenza virus. 1992, Pubmed
Hirsch, SIV adaptation to human cells. 1989, Pubmed
Ho, Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. 1995, Pubmed
Holm, Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure. 2004, Pubmed
Holsinger, Influenza A virus M2 ion channel protein: a structure-function analysis. 1994, Pubmed , Xenbase
Hongo, Detection of ion channel activity in Xenopus laevis oocytes expressing Influenza C virus CM2 protein. 2004, Pubmed , Xenbase
Hongo, Characterization of a second protein (CM2) encoded by RNA segment 6 of influenza C virus. 1997, Pubmed
Hsu, Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. 2004, Pubmed
Huang, Membrane interactions of a novel viral enterotoxin: rotavirus nonstructural glycoprotein NSP4. 2001, Pubmed
Huang, Is the 135S poliovirus particle an intermediate during cell entry? 2000, Pubmed
Impraim, Nature of virally mediated changes in membrane permeability to small molecules. 1980, Pubmed
Iwatani, Modification of virus infectivity by cytoplasmic tail of HIV-1 TM protein. 2001, Pubmed
Kalia, Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorporation. 2003, Pubmed
Kilby, Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. 1998, Pubmed
Kim, Leucine zipper domain of HIV-1 gp41 interacted specifically with alpha-catenin. 2002, Pubmed
Kim, The cytoplasmic domain of HIV-1 gp41 interacts with the carboxyl-terminal region of alpha-catenin. 1999, Pubmed
Kliger, A leucine zipper-like sequence from the cytoplasmic tail of the HIV-1 envelope glycoprotein binds and perturbs lipid bilayers. 1997, Pubmed
Klimkait, The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release. 1990, Pubmed
Kodama, Significance of premature stop codons in env of simian immunodeficiency virus. 1989, Pubmed
Koenig, Effect of the conformation of a peptide from gp41 on binding and domain formation in model membranes. 1995, Pubmed
Kort, Impairment of excitatory amino acid transport in astroglial cells infected with the human immunodeficiency virus type 1. 1998, Pubmed
Kukol, Structure of the influenza C virus CM2 protein transmembrane domain obtained by site-specific infrared dichroism and global molecular dynamics searching. 2000, Pubmed
Lawn, Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection. 2001, Pubmed
Lee, Multimerization potential of the cytoplasmic domain of the human immunodeficiency virus type 1 transmembrane glycoprotein gp41. 2000, Pubmed
Lee, Role of the carboxy-terminal portion of the HIV-1 transmembrane protein in viral transmission and cytopathogenicity. 1989, Pubmed
Levy, Pathogenesis of human immunodeficiency virus infection. 1993, Pubmed
Levy, Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. 1984, Pubmed
Liu, Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. 1996, Pubmed
Loewy, The 6-kilodalton membrane protein of Semliki Forest virus is involved in the budding process. 1995, Pubmed
Luciw, Importance of the intracytoplasmic domain of the simian immunodeficiency virus (SIV) envelope glycoprotein for pathogenesis. 1998, Pubmed
Ma, Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1. 2002, Pubmed
Maddon, The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. 1986, Pubmed
Maier, Vacuolar myelopathy with multinucleated giant cells in the acquired immune deficiency syndrome (AIDS). Light and electron microscopic distribution of human immunodeficiency virus (HIV) antigens. 1989, Pubmed
Makutonina, Human immunodeficiency virus infection of T-lymphoblastoid cells reduces intracellular pH. 1996, Pubmed
Maldarelli, Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein. 1993, Pubmed
Margottin, A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. 1998, Pubmed
Marion, A two-dimensional NMR study of the antimicrobial peptide magainin 2. 1988, Pubmed , Xenbase
Masur, An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. 1981, Pubmed
McMichael, Memory CD8+ T cells in HIV infection. 2000, Pubmed
Mclean, In vivo estimates of division and death rates of human T lymphocytes. 1995, Pubmed
Melton, Alphavirus 6K proteins form ion channels. 2002, Pubmed
Miceli, Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes. 2001, Pubmed
Micklem, Surface components involved in virally mediated membrane changes. 1977, Pubmed
Miedema, Changing virus-host interactions in the course of HIV-1 infection. 1994, Pubmed
Miller, Alterations in cell membrane permeability by the lentivirus lytic peptide (LLP-1) of HIV-1 transmembrane protein. 1993, Pubmed
Miller, Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein. 1993, Pubmed
Miller, A structural correlation between lentivirus transmembrane proteins and natural cytolytic peptides. 1991, Pubmed
Mohri, Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. 1998, Pubmed
Montagnier, Historical essay. A history of HIV discovery. 2002, Pubmed
Montal, Structure-function correlates of Vpu, a membrane protein of HIV-1. 2003, Pubmed
Moore, Sindbis virus infection decreases intracellular pH: alkaline medium inhibits processing of Sindbis virus polyproteins. 1988, Pubmed
Moreno, The membranotropic regions of the endo and ecto domains of HIV gp41 envelope glycoprotein. 2006, Pubmed
Morris, Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VIII. Pathological consequences of rotavirus infection and its enterotoxin. 2001, Pubmed
Morris, NSP4 elicits age-dependent diarrhea and Ca(2+)mediated I(-) influx into intestinal crypts of CF mice. 1999, Pubmed
Mould, Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes. 2003, Pubmed , Xenbase
Mould, Permeation and activation of the M2 ion channel of influenza A virus. 2000, Pubmed , Xenbase
Murzyn, Construction of a toroidal model for the magainin pore. 2003, Pubmed , Xenbase
Nieva, Membrane-permeabilizing motif in Semliki forest virus E1 glycoprotein. 2004, Pubmed
Nieva, Mechanisms of membrane permeabilization by picornavirus 2B viroporin. 2003, Pubmed
Nokta, Protein kinase C and intracellular free Ca++: relationship to human immunodeficiency virus (HIV)-induced cellular hyporesponsiveness. 1994, Pubmed
Ono, Plasma membrane rafts play a critical role in HIV-1 assembly and release. 2001, Pubmed
Park, Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1. 2003, Pubmed
Perelson, HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. 1996, Pubmed
Phadke, Lentivirus lytic peptide 1 perturbs both outer and inner membranes of Serratia marcescens. 2002, Pubmed
Phadke, Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model. 2003, Pubmed
Philpott, HIV-1 coreceptor usage, transmission, and disease progression. 2003, Pubmed
Piatak, High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. 1993, Pubmed
Piller, Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers. 1996, Pubmed
Pinto, Influenza virus M2 protein has ion channel activity. 1992, Pubmed , Xenbase
Plymale, Concentration-dependent differential induction of necrosis or apoptosis by HIV-1 lytic peptide 1. 1999, Pubmed
Plymale, Both necrosis and apoptosis contribute to HIV-1-induced killing of CD4 cells. 1999, Pubmed
Popik, Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells. 2002, Pubmed
Premkumar, Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. 2004, Pubmed
Premkumar, An amino-acid substitution in the influenza-B NB protein affects ion-channel gating. 2004, Pubmed
Pugliese, A review of HIV-1 Tat protein biological effects. 2005, Pubmed
Rasheed, Cell killing by ultraviolet-inactivated human immunodeficiency virus. 1986, Pubmed
Rousso, Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. 2000, Pubmed
Sandoval, Poliovirus infection and expression of the poliovirus protein 2B provoke the disassembly of the Golgi complex, the organelle target for the antipoliovirus drug Ro-090179. 1997, Pubmed
Sanz, Interfacial domains in Sindbis virus 6K protein. Detection and functional characterization. 2003, Pubmed
Sanz, Semliki Forest virus 6K protein modifies membrane permeability after inducible expression in Escherichia coli cells. 1994, Pubmed
Schubert, The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains. 1996, Pubmed
Shacklett, The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques. 2000, Pubmed
Sherman, Insights into the biology of HIV-1 viral protein R. 2002, Pubmed
Sherman, Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr. 2001, Pubmed
Shimizu, Analysis of a human immunodeficiency virus type 1 isolate carrying a truncated transmembrane glycoprotein. 1992, Pubmed
Shimizu, Shorter size of transmembrane glycoprotein of an HIV-1 isolate. 1990, Pubmed
Simon, HIV-1 dynamics in vivo: implications for therapy. 2003, Pubmed
Somasundaran, A major mechanism of human immunodeficiency virus-induced cell killing does not involve cell fusion. 1987, Pubmed
Srinivas, Membrane interactions of synthetic peptides corresponding to amphipathic helical segments of the human immunodeficiency virus type-1 envelope glycoprotein. 1992, Pubmed
Strebel, Virus-host interactions: role of HIV proteins Vif, Tat, and Rev. 2003, Pubmed
Strebel, A novel gene of HIV-1, vpu, and its 16-kilodalton product. 1988, Pubmed
Strebel, Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein. 1989, Pubmed
Sugrue, Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel. 1991, Pubmed
Suhy, Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles. 2000, Pubmed
Sung, Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells. 2001, Pubmed
Sunstrom, Ion channels formed by NB, an influenza B virus protein. 1996, Pubmed
Sáez-Cirión, The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide. 2003, Pubmed
Takeda, Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture. 2002, Pubmed
Takeya, Immunohistochemical characterization of multinucleated giant cells in the brain of a Japanese AIDS patient. 1991, Pubmed
Tencza, Effect of amino acid substitutions on calmodulin binding and cytolytic properties of the LLP-1 peptide segment of human immunodeficiency virus type 1 transmembrane protein. 1995, Pubmed
Tencza, Calmodulin-binding function of LLP segments from the HIV type 1 transmembrane protein is conserved among natural sequence variants. 1997, Pubmed
Tencza, Novel antimicrobial peptides derived from human immunodeficiency virus type 1 and other lentivirus transmembrane proteins. 1997, Pubmed
Tosteson, Reconstitution of the influenza virus M2 ion channel in lipid bilayers. 1994, Pubmed , Xenbase
Tosteson, Poliovirus binding to its receptor in lipid bilayers results in particle-specific, temperature-sensitive channels. 2004, Pubmed
Tosteson, Characterization of the ion channels formed by poliovirus in planar lipid membranes. 1997, Pubmed
Tzounopoulos, Induction of endogenous channels by high levels of heterologous membrane proteins in Xenopus oocytes. 1995, Pubmed , Xenbase
Ulug, Inhibition of Na+K+ATPase activity in membranes of Sindbis virus-infected chick cells. 1996, Pubmed
Ulug, The role of monovalent cation transport in Sindbis virus maturation and release. 1989, Pubmed
Vago, Reduced frequency of HIV-induced brain lesions in AIDS patients treated with zidovudine. 1993, Pubmed
Van kuppeveld, Structure-function analysis of coxsackie B3 virus protein 2B. 1997, Pubmed
Venable, Theoretically determined three-dimensional structures for amphipathic segments of the HIV-1 gp41 envelope protein. 1989, Pubmed
Voss, Reduction of human immunodeficiency virus production and cytopathic effects by inhibitors of the Na+/K+/2Cl- cotransporter. 1996, Pubmed
Voss, Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus. 1996, Pubmed
Wahl, Viral and host cofactors facilitate HIV-1 replication in macrophages. 2003, Pubmed
Wang, Direct measurement of the influenza A virus M2 protein ion channel activity in mammalian cells. 1994, Pubmed
Watanabe, Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles. 2002, Pubmed
Wei, Viral dynamics in human immunodeficiency virus type 1 infection. 1995, Pubmed
Welch, Characterization of a small, nonstructural viral polypeptide present late during infection of BHK cells by Semliki Forest virus. 1980, Pubmed
Wengler, In vitro analysis of factors involved in the disassembly of Sindbis virus cores by 60S ribosomal subunits identifies a possible role of low pH. 2002, Pubmed
Wengler, Entry of alphaviruses at the plasma membrane converts the viral surface proteins into an ion-permeable pore that can be detected by electrophysiological analyses of whole-cell membrane currents. 2003, Pubmed
Werner, HIV-1 Nef protein exhibits structural and functional similarity to scorpion peptides interacting with K+ channels. 1991, Pubmed
Wilk, Retained in vitro infectivity and cytopathogenicity of HIV-1 despite truncation of the C-terminal tail of the env gene product. 1992, Pubmed
Willey, Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4. 1992, Pubmed
Wimley, Determining the membrane topology of peptides by fluorescence quenching. 2000, Pubmed
Wray, Solution structure of the hydrophilic region of HIV-1 encoded virus protein U (Vpu) by CD and 1H NMR spectroscopy. 1995, Pubmed
Wyma, Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles. 2000, Pubmed
Yang, Barrel-stave model or toroidal model? A case study on melittin pores. 2001, Pubmed
Yu, Mutations in the cytoplasmic domain of human immunodeficiency virus type 1 transmembrane protein impair the incorporation of Env proteins into mature virions. 1993, Pubmed
Zebedee, Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. 1988, Pubmed
Zhang, Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenviroments: an important stage for viral infection of nondividing cells. 1996, Pubmed
Zhu, Genotypic and phenotypic characterization of HIV-1 patients with primary infection. 1993, Pubmed
de Jong, Determinants for membrane association and permeabilization of the coxsackievirus 2B protein and the identification of the Golgi complex as the target organelle. 2003, Pubmed
de Jong, Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication. 2004, Pubmed
van Kuppeveld, Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy. 2002, Pubmed