Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
Yamashita H
,
ten Dijke P
,
Huylebroeck D
,
Sampath TK
,
Andries M
,
Smith JC
,
Heldin CH
,
Miyazono K
.
???displayArticle.abstract???
Proteins in the TGF-beta superfamily transduce their effects through binding to type I and type II serine/threonine kinase receptors. Osteogenic protein-1 (OP-1, also known as bone morphogenetic protein-7 or BMP-7), a member of the TGF-beta superfamily which belongs to the BMP subfamily, was found to bind activin receptor type I (ActR-I), and BMP receptors type IA (BMPR-IA) and type IB (BMPR-IB) in the presence of activin receptors type II (ActR-II) and type IIB (ActR-IIB). The binding affinity of OP-1 to ActR-II was two- to threefold lower than that of activin A. A transcriptional activation signal was transduced after binding of OP-1 to the complex of ActR-I and ActR-II, or that of BMPR-IB and ActR-II. These results indicate that ActR-II can act as a functional type II receptor for OP-1, as well as for activins. Some of the known biological effects of activin were observed for OP-1, including growth inhibition and erythroid differentiation induction. Compared to activin, OP-1 was shown to be a poor inducer of mesoderm in Xenopus embryos. Moreover, follistatin, an inhibitor of activins, was found to inhibit the effects of OP-1, if added at a 10-fold excess. However, certain effects of activin, like induction of follicle stimulating hormone secretion in rat pituitary cells were not observed for OP-1. OP-1 has overlapping binding specificities with activins, and shares certain but not all of the functional effects of activins. Thus, OP-1 may have broader effects in vivo than hitherto recognized.
Andersson,
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
1989, Pubmed
Andersson,
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
1989,
Pubmed
Attisano,
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
1993,
Pubmed
Attisano,
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.
1992,
Pubmed
Bassing,
A transforming growth factor beta type I receptor that signals to activate gene expression.
1994,
Pubmed
Burt,
Evolution of the transforming growth factor-beta superfamily.
1994,
Pubmed
Cooke,
The organization of mesodermal pattern in Xenopus laevis: experiments using a Xenopus mesoderm-inducing factor.
1987,
Pubmed
,
Xenbase
Cunliffe,
Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.
1994,
Pubmed
,
Xenbase
Cárcamo,
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
1994,
Pubmed
Dale,
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.
1992,
Pubmed
,
Xenbase
Denef,
Cell-to-cell communication in peptide target cells of anterior pituitary.
1989,
Pubmed
Ebner,
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.
1993,
Pubmed
Ebner,
Determination of type I receptor specificity by the type II receptors for TGF-beta or activin.
1993,
Pubmed
Estevez,
The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.
1993,
Pubmed
Franzén,
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
1993,
Pubmed
Frolik,
Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.
1984,
Pubmed
Graff,
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo.
1994,
Pubmed
,
Xenbase
He,
Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family.
1993,
Pubmed
Hildén,
Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor.
1994,
Pubmed
Howard,
Analysis of gastrulation: different types of gastrulation movement are induced by different mesoderm-inducing factors in Xenopus laevis.
1993,
Pubmed
,
Xenbase
Huylebroeck,
Expression and processing of the activin-A/erythroid differentiation factor precursor: a member of the transforming growth factor-beta superfamily.
1990,
Pubmed
Ichijo,
Characterization of in vivo phosphorylation of activin type II receptor.
1993,
Pubmed
Inagaki,
Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.
1993,
Pubmed
Jones,
DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
1992,
Pubmed
,
Xenbase
Jones,
Osteogenic protein-1 (OP-1) expression and processing in Chinese hamster ovary cells: isolation of a soluble complex containing the mature and pro-domains of OP-1.
1994,
Pubmed
Kingsley,
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
1994,
Pubmed
Koenig,
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.
1994,
Pubmed
Laiho,
Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events.
1991,
Pubmed
Laiho,
Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.
1990,
Pubmed
Lin,
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
1992,
Pubmed
Massagué,
The TGF-beta family and its composite receptors.
1994,
Pubmed
Mathews,
Cloning of a second type of activin receptor and functional characterization in Xenopus embryos.
1992,
Pubmed
,
Xenbase
Mathews,
Expression cloning of an activin receptor, a predicted transmembrane serine kinase.
1991,
Pubmed
Mathews,
Activin receptors and cellular signaling by the receptor serine kinase family.
1994,
Pubmed
Matsuzaki,
A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.
1993,
Pubmed
Murata,
Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.
1988,
Pubmed
Nakamura,
Activin-binding protein from rat ovary is follistatin.
1990,
Pubmed
Ogawa,
Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation.
1992,
Pubmed
Okabe,
Long-term cultivation and differentiation of human erythroleukemia cells in a protein-free chemically defined medium.
1984,
Pubmed
Okadome,
Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.
1994,
Pubmed
Ozkaynak,
OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.
1990,
Pubmed
,
Xenbase
Paralkar,
Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen.
1992,
Pubmed
Perides,
Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins.
1994,
Pubmed
Reddi,
Regulation of cartilage and bone differentiation by bone morphogenetic proteins.
1992,
Pubmed
Sampath,
Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.
1992,
Pubmed
Schulte-Merker,
Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?
1994,
Pubmed
,
Xenbase
Schwall,
Erythroid differentiation bioassays for activin.
1991,
Pubmed
Slack,
Regional biosynthetic markers in the early amphibian embryo.
1984,
Pubmed
Smith,
Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.
1991,
Pubmed
,
Xenbase
Smith,
Dorsalization and neural induction: properties of the organizer in Xenopus laevis.
1983,
Pubmed
,
Xenbase
Smith,
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
1990,
Pubmed
,
Xenbase
Suzuki,
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
1994,
Pubmed
,
Xenbase
Thomsen,
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.
1990,
Pubmed
,
Xenbase
Tsuchida,
Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor.
1993,
Pubmed
Ueno,
Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.
1987,
Pubmed
Vukicevic,
Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin.
1989,
Pubmed
Wozney,
Bone morphogenetic proteins.
1989,
Pubmed
Wrana,
TGF beta signals through a heteromeric protein kinase receptor complex.
1992,
Pubmed
Wrana,
Mechanism of activation of the TGF-beta receptor.
1994,
Pubmed
Xu,
Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.
1994,
Pubmed
ten Dijke,
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
1994,
Pubmed
ten Dijke,
Characterization of type I receptors for transforming growth factor-beta and activin.
1994,
Pubmed
ten Dijke,
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
1993,
Pubmed
ten Dijke,
Serine/threonine kinase receptors.
1994,
Pubmed
van den Eijnden-Van Raaij,
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction.
1990,
Pubmed
,
Xenbase
