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A-type potassium channels expressed from Shaker locus cDNA.
Iverson LE
,
Tanouye MA
,
Lester HA
,
Davidson N
,
Rudy B
.
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A-type K+ currents are expressed in Xenopus oocytes injected with in vitro-synthesized transcripts from cDNAs for the Drosophila Shaker (Sh) locus. A single Sh gene product, possibly as a multimer, is sufficient for formation of functional A channels. Various Sh RNAs express A currents with distinct kinetic properties. An analysis of structure-function relationships shows that the conserved central region of Sh polypeptides determines ionic selectivity and overall channel behavior, whereas the divergent amino and carboxyl termini can modify channel kinetics. Alternative splicing of Sh gene transcripts may provide one mechanism for the generation of K+ channel diversity.
Baumann,
Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I(A) channel transcript with homology to vertebrate Na channel.
1987, Pubmed
Baumann,
Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I(A) channel transcript with homology to vertebrate Na channel.
1987,
Pubmed
Catterall,
Molecular properties of voltage-sensitive sodium channels.
1986,
Pubmed
Guy,
Molecular model of the action potential sodium channel.
1986,
Pubmed
Kamb,
Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.
1987,
Pubmed
Klein,
Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia.
1982,
Pubmed
Krieg,
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.
1984,
Pubmed
,
Xenbase
Noda,
Existence of distinct sodium channel messenger RNAs in rat brain.
,
Pubmed
Rudy,
Diversity and ubiquity of K channels.
1988,
Pubmed
Salkoff,
Genetic and voltage-clamp analysis of a Drosophila potassium channel.
1983,
Pubmed
Salkoff,
Ion currents in Drosophila flight muscles.
1983,
Pubmed
Schwarz,
Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.
1988,
Pubmed
Solc,
Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila.
1987,
Pubmed
Tempel,
Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.
1987,
Pubmed
Timpe,
Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
Wu,
Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alteration of potassium currents in Shaker mutants.
1985,
Pubmed
