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Mol Cell Biol
1990 Nov 01;1011:6046-50. doi: 10.1128/mcb.10.11.6046-6050.1990.
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Manipulations of cholinesterase gene expression modulate murine megakaryocytopoiesis in vitro.
Patinkin D
,
Seidman S
,
Eckstein F
,
Benseler F
,
Zakut H
,
Soreq H
.
Abstract
Megakaryocytopoiesis was selectively inhibited in cultured murine bone marrow cells by a 15-mer oligodeoxynucleotide complementary to the initiator AUG region in butyrylcholinesterase mRNA. Furthermore, conditioned medium from Xenopus oocytes producing recombinant butyrylcholinesterase stimulated megakaryocytopoiesis. These observations implicate butyrylcholinesterase in megakaryocytopoiesis and suggest application of oligodeoxynucleotides for modulating bone marrow development.
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Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation.
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Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation.
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Quantitation of megakaryocytopoiesis in liquid culture by enzymatic determination of acetylcholinesterase.
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Nucleoside phosphorothioates.
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1989,
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Purification of human platelet-derived growth factor.
1987,
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Regulators of thrombopoiesis: their biochemistry and physiology.
1989,
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Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro.
1989,
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Johnson,
The acetylcholinesterase genes of C. elegans: identification of a third gene (ace-3) and mosaic mapping of a synthetic lethal phenotype.
1988,
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Lapidot-Lifson,
Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis.
1989,
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Spatiotemporal relationship of embryonic cholinesterases with cell proliferation in chicken brain and eye.
1987,
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Malinger,
Cholinoceptive properties of human primordial, preantral, and antral oocytes: in situ hybridization and biochemical evidence for expression of cholinesterase genes.
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Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.
1987,
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Mercola,
Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos.
1988,
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Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy.
1985,
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Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.
1987,
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Rotshenker,
The transneuronal induction of sprouting and synapse formation in intact mouse muscles.
1985,
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Soreq,
Expression and tissue-specific assembly of human butyrylcholine esterase in microinjected Xenopus laevis oocytes.
1989,
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The biosynthesis of biologically active proteins in mRNA-microinjected Xenopus oocytes.
1985,
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1987,
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Regulation of very primitive, multipotent, hemopoietic cells by hemopoietin-1.
1986,
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Oligodeoxynucleotides as inhibitors of gene expression: a review.
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Evidence for a novel growth factor in Xenopus oocytes.
1989,
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Wickstrom,
Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.
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Williams,
Multiple levels of regulation of megakaryocytopoiesis.
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Zheng,
Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor.
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