Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1990 Jul 01;8713:5227-31.
Show Gene links
Show Anatomy links
Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals.
McCormack T
,
Vega-Saenz de Miera EC
,
Rudy B
.
???displayArticle.abstract???
We report the cloning of RKShIIIA, a cDNA encoding a K+ channel sequence expressed in rat brain. This cDNA encodes K+ channel subunits that express in Xenopus oocytes a slow, 4-aminopyridine- and tetraethylammonium-sensitive, delayed rectifier-type K+ channel activated by large membrane depolarizations. This gene belongs to the Shaker (Sh) family of K+ channel genes, since the predicted protein has the same overall structure and shows significant homology to other members of this family. However, RKShIIIA cannot be assigned to either of the two known classes of Sh-family genes in mammals based on sequence analysis. Notable features of the RKShIIIA protein product include a probable cytoplasmic loop rich in prolines and a stretch very homologous to the Drosophila Shaw protein, both near the amino terminus.
Bezanilla,
Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons.
1972, Pubmed
Bezanilla,
Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons.
1972,
Pubmed
Butler,
A family of putative potassium channel genes in Drosophila.
1989,
Pubmed
Catterall,
Structure and function of voltage-sensitive ion channels.
1988,
Pubmed
Christie,
Expression of a cloned rat brain potassium channel in Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Eylar,
The chemical and immunologic properties of the basic A1 protein of myelin.
1972,
Pubmed
Feinberg,
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
1983,
Pubmed
Frech,
A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.
1989,
Pubmed
,
Xenbase
Hart,
Nucleoplasmic and cytoplasmic glycoproteins.
1989,
Pubmed
Haugland,
A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila.
1990,
Pubmed
Iverson,
A-type potassium channels expressed from Shaker locus cDNA.
1988,
Pubmed
,
Xenbase
Kamb,
Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification.
1989,
Pubmed
Kamb,
Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity.
1988,
Pubmed
Llinás,
The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.
1988,
Pubmed
Marshall,
The nature and metabolism of the carbohydrate-peptide linkages of glycoproteins.
1974,
Pubmed
McCormack,
Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals.
1991,
Pubmed
McKinnon,
Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family.
1989,
Pubmed
,
Xenbase
NULL,
Leucine-zipper motif update.
1989,
Pubmed
Numa,
Molecular basis for the function of ionic channels.
1986,
Pubmed
Pongs,
Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.
1988,
Pubmed
Rehm,
Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I.
1988,
Pubmed
Rudy,
Diversity and ubiquity of K channels.
1988,
Pubmed
Rudy,
At least two mRNA species contribute to the properties of rat brain A-type potassium channels expressed in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
Schwarz,
Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.
1988,
Pubmed
Stühmer,
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
1989,
Pubmed
,
Xenbase
Südhof,
Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.
1989,
Pubmed
Takumi,
Cloning of a membrane protein that induces a slow voltage-gated potassium current.
1988,
Pubmed
,
Xenbase
Tempel,
Cloning of a probable potassium channel gene from mouse brain.
1988,
Pubmed
Yeh,
Dynamics of aminopyridine block of potassium channels in squid axon membrane.
1976,
Pubmed
Yokoyama,
Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs.
1989,
Pubmed
,
Xenbase
