Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
2001 Sep 11;9819:10739-44. doi: 10.1073/pnas.191361698.
Show Gene links
Show Anatomy links
Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor.
Schreiber AM
,
Das B
,
Huang H
,
Marsh-Armstrong N
,
Brown DD
.
???displayArticle.abstract???
Metamorphosis of anuran tadpoles is controlled by thyroid hormone (TH). Here we demonstrate that transgenic Xenopus laevis tadpoles expressing a dominant negative form of TH receptor-alpha are resistant to a wide variety of the metamorphic changes induced by TH. This result confirms that TH receptors mediate both early and late developmental programs of metamorphosis as diverse as growth in the brain, limb buds, nose and Meckel's cartilage, remodeling of the intestine, and death and resorption of the gills and tail.
Banker,
Thyroid hormone receptor can modulate retinoic acid-mediated axis formation in frog embryogenesis.
1993, Pubmed,
Xenbase
Banker,
Thyroid hormone receptor can modulate retinoic acid-mediated axis formation in frog embryogenesis.
1993,
Pubmed
,
Xenbase
Berry,
The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs.
1998,
Pubmed
,
Xenbase
Bou-Gharios,
A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice.
1996,
Pubmed
Brown,
The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis.
1996,
Pubmed
,
Xenbase
Eliceiri,
Quantitation of endogenous thyroid hormone receptors alpha and beta during embryogenesis and metamorphosis in Xenopus laevis.
1994,
Pubmed
,
Xenbase
Forrest,
Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes.
1990,
Pubmed
Gauthier,
Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.
1999,
Pubmed
Göthe,
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.
1999,
Pubmed
Huang,
Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase.
1999,
Pubmed
,
Xenbase
Kanamori,
The regulation of thyroid hormone receptor beta genes by thyroid hormone in Xenopus laevis.
1992,
Pubmed
,
Xenbase
Kobayashi,
Regionally regulated conversion of protein expression in the skin during anuran metamorphosis.
1996,
Pubmed
,
Xenbase
Kroll,
Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation.
1996,
Pubmed
,
Xenbase
Marsh-Armstrong,
Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase.
1999,
Pubmed
,
Xenbase
Puzianowska-Kuznicka,
Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis.
1997,
Pubmed
,
Xenbase
Sap,
The c-erb-A protein is a high-affinity receptor for thyroid hormone.
,
Pubmed
Turner,
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
1994,
Pubmed
,
Xenbase
Ulisse,
Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo.
1996,
Pubmed
,
Xenbase
Wang,
A gene expression screen.
1991,
Pubmed
,
Xenbase
Wang,
Thyroid hormone-induced gene expression program for amphibian tail resorption.
1993,
Pubmed
,
Xenbase
Weinberger,
The c-erb-A gene encodes a thyroid hormone receptor.
,
Pubmed
Wong,
Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity.
1997,
Pubmed
Yaoita,
Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail.
1997,
Pubmed
,
Xenbase
Yaoita,
Xenopus laevis alpha and beta thyroid hormone receptors.
1990,
Pubmed
,
Xenbase
Yaoita,
A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis.
1990,
Pubmed
,
Xenbase
