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XB-ART-23004
Dev Immunol 1993 Jan 01;33:223-30. doi: 10.1155/1993/63626.
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Transforming growth factor beta (TGF beta) is produced by and influences the proliferative response of Xenopus laevis lymphocytes.

Haynes L , Cohen N .


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Both TGF beta 2 and 5 have been described in the South African clawed frog Xenopus laevis and have been cloned from the tadpole-derived fibroblast cell line, XTC. Because TGF beta has such a profound inhibitory effect on the mammalian immune system, this study was performed to determine whether TGF beta: (a) has any in vitro effects on the growth of Xenopus lymphoblasts, and (b) is produced by mitogen-activated Xenopus lymphocytes. Following stimulation with mitogen or alloantigen, T lymphocytes from Xenopus secrete a T-cell growth factor (TCGF) that is functionally homologous to mammalian interleukin-2 (IL-2). Both recombinant human TGF beta 1 and Xenopus TGF beta 5 inhibit TCGF-induced proliferation of Xenopus splenic blasts and this inhibition can be reversed with anti-pan TGF beta antiserum. The Xenopus mitogen-induced saturated ammonium sulfate precipitated TCGF-containing supernatant (SAS TCGF SN) also contains latent TGF beta as assayed on mink lung fibroblasts and Xenopus splenic blasts, and experiments utilizing anti-TGF beta antiserum showed that only TGF beta 5 is present in this supernatant.

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Species referenced: Xenopus laevis
Genes referenced: kcne1 tgfb1