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Immunogenetics
1982 Jan 01;162:103-16. doi: 10.1007/bf00364398.
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Immunogenetic aspects of in vivo allotolerance induction during the ontogeny of Xenopus laevis.
DiMarzo SJ
,
Cohen N
.
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This study describes the ontogeny of allograft immunity in a partially inbred strain of frogs (Xenopus laevis). At various times during the frogs' premetamorphic, perimetamorphic, and postmetamorphic life, major histocompatibility complex (MHC) homozygous strain JJ Xenopus (MHC haplotype j) were grafted with skin from adult donors of defined MHC homozygous (j,f) and heterozygous (j/f,f/h) haplotypes. This protocol reveals that destructive allograft reactivity to MHC alloantigens in Xenopus matures slowly and that allotolerance can be induced to such MHC-encoded antigens throughout larval life. The ultimate fate of an MHC disparate transplant (survival or rejection) is dependent on several interacting variables, which include antigen dose, haplotype dose, and the developmental stage of the host frog at the time of transplantation. In contrast, minor H-locus disparate (MHC compatible) grafts never appear to be rejected by hosts grafted at any larval stage.
Bernardini,
[Tolerance of cutaneous allografts in Xenopus laevis. Influence of the size and age of the graft].
1970, Pubmed,
Xenbase
Bernardini,
[Tolerance of cutaneous allografts in Xenopus laevis. Influence of the size and age of the graft].
1970,
Pubmed
,
Xenbase
Billingham,
The passenger cell concept in transplantation immunology.
1971,
Pubmed
Chardonnens,
Induction of skin allograft tolerance during metamorphosis of the toad Xenopus laevis: a possible model for studying generation of self tolerance to histocompatibility antigens.
1973,
Pubmed
,
Xenbase
Chardonnens,
Tissue typing by skin grafting during metamorphosis of the toad Xenopus laevis (Daudin).
1975,
Pubmed
,
Xenbase
DiMarzo,
An in vivo study of the ontogeny of alloreactivity in the frog, Xenopus laevis.
1982,
Pubmed
,
Xenbase
Du Pasquier,
Active suppression of the allogeneic histocompatibility reactions during the metamorphosis of the clawed toad Xenopus.
1980,
Pubmed
,
Xenbase
Hasek,
Complexity of the state of immunological tolerance.
1979,
Pubmed
Hildemann,
Immunogenetic components of weaker histoincompatibility systems in mice.
1970,
Pubmed
Hildemann,
Components and concepts of antigenic strength.
1969,
Pubmed
Holán,
Specific suppression of antigen-reactive cells in neonatal transplantation tolerance.
1978,
Pubmed
Katagiri,
Xenopus laevis as a model for the study of immunology.
1978,
Pubmed
,
Xenbase
LITCHFIELD,
A method for rapid graphic solution of time-per cent effect curves.
1949,
Pubmed
Lapp,
Significance of allelic dosage and graft size on tolerance induction by H-1-incompatible skin grafts.
1970,
Pubmed
Lapp,
The effects of allelic dosage and graft size on skin graft survival across a weak histocompatibility barrier.
1967,
Pubmed
MCKHANN,
TRANSPLANTATION STUDIES OF STRONG AND WEAK HISTOCOMPATIBILITY BARRIERS IN MICE. II. TOLERANCE.
1964,
Pubmed
Manning,
Histogenesis of lymphoid organs in larvae of the South African clawed toad, Xenopus laevis (Daudin).
1969,
Pubmed
,
Xenbase
Williams,
Host repopulation of endothelium.
1971,
Pubmed
