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XB-ART-25530
Biochem Biophys Res Commun 1990 Oct 15;1721:300-5.
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Novel effect of azide on sodium channel of Xenopus oocytes.

Ando H .


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Bath application of a few mM of sodium azide to a voltage clamped oocyte activated a voltage dependent Na+ current. Characteristics of the azide-induced current were the same as those of already described Na+ current induced by prolonged depolarization. The Na+ current induced either by azide or depolarization was suppressed by the application of Ca2+ channel blockers (Diltiazem and La3+). Azide is known to affect some metabolic processes (ATP and cGMP production etc.), but the present effect could not be attributed to metabolic actions.

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