Biochem Biophys Res Commun 1989 Aug 15;1623:1535-40.

E-series prostaglandins activate cAMP-mediated potassium currents in follicle-enclosed Xenopus oocyte.

Abstract
Receptor-mediated responses to prostaglandins E1 and E2 are shown by electrophysiological methods in follicle-enclosed oocytes of Xenopus laevis. In voltage-clamped oocytes, prostaglandins E1 and E2 elicited an outward hyperpolarizing current. This outward membrane current was caused by an increase in K+ conductance. The prostaglandin-induced current was augmented by adenylate cyclase activator, forskolin, and by phosphodiesterase inhibitor, theophylline, indicating that adenosine 3', 5'-cyclic monophosphate (cAMP) is involved in activating the K+ current. The prostaglandin responses were either abolished or greatly reduced by removing follicular cells with collagenase, suggesting that prostaglandin receptors reside in the follicular cells.

PubMed ID: 2548500
Article link: Biochem Biophys Res Commun


Genes referenced: camp