XB-ART-2101
Cell
2005 Mar 25;1206:736-7. doi: 10.1016/j.cell.2005.03.005.
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Axis formation--beta-catenin catches a Wnt.
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In this issue of Cell, the Heasman group implicates Wnt11 as a component of the canonical Wnt signaling pathway that specifies Xenopus laevis axis formation (Tao et al., 2005). This important work not only identifies a long-sought-after dorsalizing factor but also highlights the pivotal role of extracellular cofactors in specifying the activation of either canonical or noncanonical Wnt pathways.
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Species referenced: Xenopus laevis
Genes referenced: tbx2 wnt11
References :
Tao,
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
2005, Pubmed,
Xenbase