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Mol Cell Biol
1992 Oct 01;1210:4590-600. doi: 10.1128/mcb.12.10.4590-4600.1992.
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Sequences in the human c-mycP2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter.
Meulia T
,
Krumm A
,
Spencer C
,
Groudine M
.
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A conditional block to transcription elongation provides one mechanism for controlling the steady-state levels of c-myc RNA in mammalian cells. Although prematurely terminated c-myc RNAs are not detectable in mammalian cells, truncated c-myc RNAs with 3' ends that map near the end of the first exon are transcribed from human c-myc templates injected into Xenopus oocytes germinal vesicles. A series of linker scanner and deletion mutants within the c-myc P2 promoter was tested in the Xenopus oocyte injection assay to determine the potential contribution of promoter elements to the elongation or premature termination of c-myc transcription. Although this analysis failed to identify sequences in the P2 promoter that significantly affect the elongation or termination of P2-initiated transcripts, our results suggest that sequences within the P2 promoter contribute to the premature termination of transcripts initiated at the upstream P1 promoter. A subset of these sequences is essential for the efficient elongation of P1-initiated transcripts through intrinsic sites of termination at the end of exon 1. These sequences affect P1 elongation when they are downstream of the site of initiation, and we hypothesize that they may be analogous to a class of prokaryotic elements required for antitermination.
Ashfield,
Transcriptional termination between the closely linked human complement genes C2 and factor B: common termination factor for C2 and c-myc?
1991, Pubmed
Ashfield,
Transcriptional termination between the closely linked human complement genes C2 and factor B: common termination factor for C2 and c-myc?
1991,
Pubmed
Asselin,
Molecular requirements for transcriptional initiation of the murine c-myc gene.
1989,
Pubmed
Ben-Asher,
Transcription of minute virus of mice, an autonomous parvovirus, may be regulated by attenuation.
1984,
Pubmed
Bentley,
Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas.
1986,
Pubmed
Bentley,
Sequence requirements for premature termination of transcription in the human c-myc gene.
1988,
Pubmed
,
Xenbase
Bentley,
Accurate, TATA box-dependent polymerase III transcription from promoters of the c-myc gene in injected Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Bentley,
A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells.
,
Pubmed
Boorstein,
Primer extension analysis of RNA.
1989,
Pubmed
Chang,
Effects of IL-3 on promoter usage, attenuation and antisense transcription of the c-myc oncogene in the IL-3-dependent Ba/F3 early pre-B cell line.
1991,
Pubmed
Eick,
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression.
1986,
Pubmed
Eick,
Expression of P0- and P3-RNA from the normal and translocated c-myc allele in Burkitt's lymphoma cells.
1990,
Pubmed
Eick,
Transcription of c-myc in human mononuclear cells is regulated by an elongation block.
1987,
Pubmed
Hay,
Attenuation in the control of SV40 gene expression.
1982,
Pubmed
Hiebert,
E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.
1989,
Pubmed
Kephart,
Stability of Drosophila RNA polymerase II elongation complexes in vitro.
1992,
Pubmed
Kerppola,
RNA polymerase: regulation of transcript elongation and termination.
1991,
Pubmed
Lindsten,
Multiple mechanisms regulate c-myc gene expression during normal T cell activation.
1988,
Pubmed
London,
Analysis of premature termination in c-myc during transcription by RNA polymerase II in a HeLa nuclear extract.
1991,
Pubmed
Maderious,
Pausing and premature termination of human RNA polymerase II during transcription of adenovirus in vivo and in vitro.
1984,
Pubmed
Mechti,
Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells.
1986,
Pubmed
Miller,
A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional block.
1989,
Pubmed
Mok,
Premature termination by human RNA polymerase II occurs temporally in the adenovirus major late transcriptional unit.
1984,
Pubmed
Nepveu,
Intragenic pausing and anti-sense transcription within the murine c-myc locus.
1986,
Pubmed
Nishikura,
Sequences involved in accurate and efficient transcription of human c-myc genes microinjected into frog oocytes.
1986,
Pubmed
,
Xenbase
Proudfoot,
Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulation.
,
Pubmed
Ray,
Cloning and characterization of a human c-myc promoter-binding protein.
1991,
Pubmed
Resnekov,
RNA polymerase II is capable of pausing and prematurely terminating transcription at a precise location in vivo and in vitro.
1989,
Pubmed
Roberts,
Distinct modes of transcription read through or terminate at the c-myc attenuator.
1992,
Pubmed
,
Xenbase
Roberts,
Phage lambda and the regulation of transcription termination.
1988,
Pubmed
Roberts,
A protein-binding site in the c-myc promoter functions as a terminator of RNA polymerase II transcription.
1992,
Pubmed
,
Xenbase
Spencer,
Control of c-myc regulation in normal and neoplastic cells.
1991,
Pubmed
Spencer,
The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.
1990,
Pubmed
,
Xenbase
Spencer,
Transcription elongation and eukaryotic gene regulation.
1990,
Pubmed
Thalmeier,
Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter.
1989,
Pubmed
Vieira,
Production of single-stranded plasmid DNA.
1987,
Pubmed
Wright,
DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc.
1989,
Pubmed
Wright,
Premature termination of transcription from the P1 promoter of the mouse c-myc gene.
1991,
Pubmed
,
Xenbase
Yanofsky,
Transcription attenuation.
1988,
Pubmed
ar-Rushdi,
Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma.
1983,
Pubmed
