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XB-ART-26313
FEBS Lett 1989 Dec 18;2591:213-6.
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A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

Noda M , Suzuki H , Numa S , Stühmer W .


Abstract
A single point mutation of the rat sodium channel II reduces its sensitivity to tetrodotoxin and saxitoxin by more than three orders of magnitude. The mutation replaces glutamic acid 387 with a glutamine and has only slight effects on the macroscopic current properties, as measured under voltage-clamp in Xenopus oocytes injected with the corresponding cDNA-derived mRNA.

PubMed ID: 2557243
Article link: FEBS Lett