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J Neurophysiol
2011 Feb 01;1052:601-14. doi: 10.1152/jn.00883.2010.
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Vocal pathway degradation in gonadectomized Xenopus laevis adults.
Zornik E
,
Yamaguchi A
.
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Reproductive behaviors of many vertebrate species are activated in adult males by elevated androgen levels and abolished by castration. Neural and muscular components controlling these behaviors contain numerous hormone-sensitive sites including motor initiation centers (such as the basal ganglia), central pattern generators (CPGs), and muscles; therefore it is difficult to confirm the role of each hormone-activated target using behavioral assays alone. Our goal was to address this issue by determining the site of androgen-induced vocal activation using male Xenopus laevis, a species in which androgen dependence of vocal activation has been previously determined. We compared in vivo calling patterns and functionality of two in vitro preparations-the isolated larynx and an isolated brain from which fictive courtship vocalizations can be evoked--in castrated and control males. The isolated larynx allowed us to test whether castrated males were capable of transducing male-typical nerve signals into vocalizations and the fictively vocalizing brain preparation allowed us to directly examine vocal CPG function separate from the issue of vocal initiation. The results indicate that all three components--vocal initiation, CPG, and larynx--require intact gonads. Vocal production decreased dramatically in castrates and laryngeal contractile properties of castrated males were demasculinized, whereas no changes were observed in control animals. In addition, fictive calls of castrates were degraded compared with those of controls. To our knowledge, this finding represents the first demonstration of gonad-dependent maintenance of a CPG for courtship behavior in adulthood. Because previous studies showed that androgen-replacement can prevent castration-induced vocal impairments, we conclude that degradation of vocal initiation centers, larynx, and CPG function are most likely due to steroid hormone deprivation.
Arnold,
Organizational and activational effects of sex steroids on brain and behavior: a reanalysis.
1985, Pubmed
Arnold,
Organizational and activational effects of sex steroids on brain and behavior: a reanalysis.
1985,
Pubmed
Arnold,
The effects of castration and androgen replacement on song, courtship, and aggression in zebra finches (Poephila guttata).
1975,
Pubmed
Arnold,
The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues.
2009,
Pubmed
Ball,
Hormonal regulation of brain circuits mediating male sexual behavior in birds.
2004,
Pubmed
Bass,
Sonic and electric fish: at the crossroads of neuroethology and behavioral neuroendocrinology.
2005,
Pubmed
Breedlove,
Sexually dimorphic motor nucleus in the rat lumbar spinal cord: response to adult hormone manipulation, absence in androgen-insensitive rats.
1981,
Pubmed
Catz,
Androgen regulation of a laryngeal-specific myosin heavy chain mRNA isoform whose expression is sexually differentiated.
1995,
Pubmed
,
Xenbase
Catz,
Sexually dimorphic expression of a laryngeal-specific, androgen-regulated myosin heavy chain gene during Xenopus laevis development.
1992,
Pubmed
,
Xenbase
Cooke,
A brain sexual dimorphism controlled by adult circulating androgens.
1999,
Pubmed
Cox,
Testosterone, growth and the evolution of sexual size dimorphism.
2009,
Pubmed
Dunlap,
Diversity of sexual dimorphism in electrocommunication signals and its androgen regulation in a genus of electric fish, Apteronotus.
1998,
Pubmed
Floody,
Testosterone stimulates ultrasound production by male hamsters.
1979,
Pubmed
Forger,
The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system.
2009,
Pubmed
Hannigan,
Androgen-induced alterations in vocalizations of female Xenopus laevis: modifiability and constraints.
1986,
Pubmed
,
Xenbase
Harding,
Hormonal specificity and activation of social behavior in male red-winged blackbirds.
1988,
Pubmed
Harding,
Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors.
2004,
Pubmed
Jordan,
Ontogeny of androgen receptor immunoreactivity in lumbar motoneurons and in the sexually dimorphic levator ani muscle of male rats.
1997,
Pubmed
Kay,
Trophic effects of androgen: development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus.
1999,
Pubmed
,
Xenbase
Kelley,
Locations of androgen-concentrating cells in the brain of Xenopus laevis: autoradiography with 3H-dihydrotestosterone.
1981,
Pubmed
,
Xenbase
Kelley,
Auditory and vocal nuclei in the frog brain concentrate sex hormones.
1980,
Pubmed
,
Xenbase
Kelley,
Neuroeffectors for vocalization in Xenopus laevis: hormonal regulation of sexual dimorphism.
1986,
Pubmed
,
Xenbase
Kurz,
Androgens regulate the dendritic length of mammalian motoneurons in adulthood.
1986,
Pubmed
Lieberburg,
High-affinity androgen binding proteins in syringeal tissues of songbirds.
1979,
Pubmed
Liu,
Individual variation and hormonal modulation of a sodium channel beta subunit in the electric organ correlate with variation in a social signal.
2007,
Pubmed
,
Xenbase
Lännergren,
Contractile properties and myosin isoenzymes of various kinds of Xenopus twitch muscle fibres.
1987,
Pubmed
,
Xenbase
Meitzen,
Plastic and stable electrophysiological properties of adult avian forebrain song-control neurons across changing breeding conditions.
2009,
Pubmed
Morrell,
Autoradiographic localization of hormone-concentrating cells in the brain of an amphibian, Xenopus laevis. II. Estradiol.
1975,
Pubmed
,
Xenbase
Nottebohm,
A brain for all seasons: cyclical anatomical changes in song control nuclei of the canary brain.
1981,
Pubmed
PHOENIX,
Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig.
1959,
Pubmed
Pan,
Effect of testosterone on functional recovery in a castrate male rat stroke model.
2005,
Pubmed
Park,
Seasonal-like plasticity of spontaneous firing rate in a songbird pre-motor nucleus.
2005,
Pubmed
Petrea,
Gender differences in stroke incidence and poststroke disability in the Framingham heart study.
2009,
Pubmed
Pfaff,
Autoradiographic localization of radioactivity in rat brain after injection of tritiated sex hormones.
1968,
Pubmed
Potter,
Androgen-induced vocal transformation in adult female African clawed frogs.
2005,
Pubmed
,
Xenbase
Rhodes,
Xenopus vocalizations are controlled by a sexually differentiated hindbrain central pattern generator.
2007,
Pubmed
,
Xenbase
Sassoon,
Androgen regulation of muscle fiber type in the sexually dimorphic larynx of Xenopus laevis.
1987,
Pubmed
,
Xenbase
Schulz,
Back to the future: The organizational-activational hypothesis adapted to puberty and adolescence.
2009,
Pubmed
Segil,
Androgen-binding levels in a sexually dimorphic muscle of Xenopus laevis.
1987,
Pubmed
,
Xenbase
Simpson,
Origin and identification of fibers in the cranial nerve IX-X complex of Xenopus laevis: Lucifer Yellow backfills in vitro.
1986,
Pubmed
,
Xenbase
Tobias,
Vocalizations by a sexually dimorphic isolated larynx: peripheral constraints on behavioral expression.
1987,
Pubmed
,
Xenbase
Tobias,
A sex difference in synaptic efficacy at the laryngeal neuromuscular junction of Xenopus laevis.
1995,
Pubmed
,
Xenbase
Tobias,
Vocal communication between male Xenopus laevis.
2004,
Pubmed
,
Xenbase
Tobias,
Rapping, a female receptive call, initiates male-female duets in the South African clawed frog.
1998,
Pubmed
,
Xenbase
Watson,
Laryngeal muscle and motor neuron plasticity in Xenopus laevis: testicular masculinization of a developing neuromuscular system.
1993,
Pubmed
,
Xenbase
Watson,
Testicular masculinization of vocal behavior in juvenile female Xenopus laevis reveals sensitive periods for song duration, rate, and frequency spectra.
1992,
Pubmed
,
Xenbase
Wetzel,
A proposed neural pathway for vocalization in South African clawed frogs, Xenopus laevis.
1985,
Pubmed
,
Xenbase
Wetzel,
Androgen and gonadotropin effects on male mate calls in South African clawed frogs, Xenopus laevis.
1983,
Pubmed
,
Xenbase
Yamaguchi,
Temperature-dependent regulation of vocal pattern generator.
2008,
Pubmed
,
Xenbase
Yamaguchi,
Functional specialization of male and female vocal motoneurons.
2003,
Pubmed
,
Xenbase
Yamaguchi,
Generating sexually differentiated vocal patterns: laryngeal nerve and EMG recordings from vocalizing male and female african clawed frogs (Xenopus laevis).
2000,
Pubmed
,
Xenbase
Yang,
Direct action of gonadotropin in brain integrates behavioral and reproductive functions.
2007,
Pubmed
,
Xenbase
Yu,
Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis.
2010,
Pubmed
,
Xenbase
Zimmermann,
Castration affects the emission of an ultrasonic vocalization in a nocturnal primate, the grey mouse lemur (Microcebus murinus).
1996,
Pubmed
Zornik,
Regulation of respiratory and vocal motor pools in the isolated brain of Xenopus laevis.
2008,
Pubmed
,
Xenbase
Zornik,
Sexually differentiated central pattern generators in Xenopus laevis.
2008,
Pubmed
,
Xenbase
Zornik,
NMDAR-dependent control of call duration in Xenopus laevis.
2010,
Pubmed
,
Xenbase
