Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-25802
Nature 1990 Jun 21;3456277:732-4. doi: 10.1038/345732a0.
Show Gene links Show Anatomy links

Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction.

van den Eijnden-Van Raaij AJ , van Zoelent EJ , van Nimmen K , Koster CH , Snoek GT , Durston AJ , Huylebroeck D .


???displayArticle.abstract???
Induction of mesoderm during early amphibian embryogenesis can be mimicked in vitro by adding growth factors, including heparin-binding and type-beta transforming growth factors (TGF-beta), to isolated ectoderm explants from Xenopus laevis embryos. Although the mesoderm-inducing factor (MIF) from X. laevis XTC cells (XTC-MIF) has properties similar to TGF-beta, this factor is still unidentified. Recently, we obtained a number of homogeneous cell lines from the heterogeneous XTC population, which differ in their MIF production. Only one, XTC-GTX-11, produced MIF, although it was similar to the rest of the clones in its production of known growth factors, including TGF-beta activity. This observation, together with the identification of activin A as a potent MIF led us to study the parallel activities of MIF and activin. Here we report an analysis of activin-like activity from XTC cells and some of the XTC clones, including XTC-GTX-11. There is a clear consistent correlation between MIF activity and presence of activin activity, indicating that XTC-MIF is the Xenopus homologue of mammalian activin.

???displayArticle.pubmedLink??? 2113616
???displayArticle.link??? Nature


Species referenced: Xenopus laevis
Genes referenced: amh inhba mif tgfb1