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Biophys J
1997 Dec 01;736:2897-906. doi: 10.1016/S0006-3495(97)78318-8.
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Calcium waves in a model with a random spatially discrete distribution of Ca2+ release sites.
Bugrim AE
,
Zhabotinsky AM
,
Epstein IR
.
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We study the propagation of intracellular calcium waves in a model that features Ca2+ release from discrete sites in the endoplasmic reticulum membrane and random spatial distribution of these sites. The results of our simulations qualitatively reproduce the experimentally observed behavior of the waves. When the level of the channel activator inositol trisphosphate is low, the wave undergoes fragmentation and eventually vanishes at a finite distance from the region of initiation, a phenomenon we refer to as an abortive wave. With increasing activator concentration, the mean distance of propagation increases. Above a critical level of activator, the wave becomes stable. We show that the heterogeneous distribution of Ca2+ channels is the cause of this phenomenon.
Atri,
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1993, Pubmed,
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Atri,
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte.
1993,
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,
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Berridge,
Elementary and global aspects of calcium signalling.
1997,
Pubmed
Cheng,
Calcium sparks and [Ca2+]i waves in cardiac myocytes.
1996,
Pubmed
Clapham,
Calcium signaling.
1995,
Pubmed
De Young,
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
1992,
Pubmed
Dupont,
Properties of intracellular Ca2+ waves generated by a model based on Ca(2+)-induced Ca2+ release.
1994,
Pubmed
,
Xenbase
Goldbeter,
Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation.
1990,
Pubmed
Li,
Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism.
1994,
Pubmed
Parker,
Elementary events of InsP3-induced Ca2+ liberation in Xenopus oocytes: hot spots, puffs and blips.
1996,
Pubmed
,
Xenbase
Parker,
Regenerative release of calcium from functionally discrete subcellular stores by inositol trisphosphate.
1991,
Pubmed
,
Xenbase
Parker,
Ca2+ transients associated with openings of inositol trisphosphate-gated channels in Xenopus oocytes.
1996,
Pubmed
,
Xenbase
Provatas,
Flame propagation in random media.
1995,
Pubmed
Roth,
A mathematical model of agonist-induced propagation of calcium waves in astrocytes.
1995,
Pubmed
Tang,
Simplification and analysis of models of calcium dynamics based on IP3-sensitive calcium channel kinetics.
1996,
Pubmed
,
Xenbase
Thorn,
Multiple, coordinated Ca2+ -release events underlie the inositol trisphosphate-induced local Ca2+ spikes in mouse pancreatic acinar cells.
1996,
Pubmed
Wagner,
Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations.
1994,
Pubmed
Watras,
Inositol 1,4,5-trisphosphate-gated channels in cerebellum: presence of multiple conductance states.
1991,
Pubmed
Yagodin,
Nonlinear propagation of agonist-induced cytoplasmic calcium waves in single astrocytes.
1994,
Pubmed
Yagodin,
Subcellular calcium oscillators and calcium influx support agonist-induced calcium waves in cultured astrocytes.
1995,
Pubmed
Yao,
Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
