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Development 2004 Aug 01;13115:3491-9. doi: 10.1242/dev.01284.
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Move it or lose it: axis specification in Xenopus.

Weaver C , Kimelman D .

A long-standing question in developmental biology is how amphibians establish a dorsoventral axis. The prevailing view has been that cortical rotation is used to move a dorsalizing activity from the bottom of the egg towards the future dorsal side. We review recent evidence that kinesin-dependent movement of particles containing components of the Wnt intracellular pathway contributes to the formation of the dorsal organizer, and suggest that cortical rotation functions to align and orient microtubules, thereby establishing the direction of particle transport. We propose a new model in which active particle transport and cortical rotation cooperate to generate a robust movement of dorsal determinants towards the future dorsal side of the embryo.

PubMed ID: 15262887
Article link: Development

Genes referenced: dvl1 dvl2 frat1 gsk3b kif5b klc1 mylkl

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