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J Neurosci
2002 Dec 15;2224:10924-34. doi: 10.1523/JNEUROSCI.22-24-10924.2002.
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Spinal inhibitory neurons that modulate cutaneous sensory pathways during locomotion in a simple vertebrate.
Li WC
,
Soffe SR
,
Roberts A
.
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During locomotion, reflex responses to sensory stimulation are usually modulated and may even be reversed. This is thought to be the result of phased inhibition, but the neurons responsible are usually not known. When the hatchling Xenopus tadpole swims, responses to cutaneous stimulation are modulated. This occurs because sensory pathway interneurons receive rhythmic glycinergic inhibition broadly in phase with the motor discharge on the same side of the trunk. We now describe a new whole-cell recording preparation of the Xenopus tadpoleCNS. This has been used with neurobiotin injection to define the passive and firing properties of spinal ascending interneurons and their detailed anatomy. Paired recordings show that they make direct, glycinergic synapses onto spinal sensory pathway interneurons, and the site of contact can be seen anatomically. During swimming, ascending interneurons fire rhythmically. Analysis shows that their firing is more variable and not as reliable as other interneurons, but the temporal pattern of their impulse activity is suitable to produce the main peak of gating inhibition in sensory pathway interneurons. Ascending interneurons are not excited at short latency after skin stimulation but are strongly active after repetitive skin stimulation, which evokes vigorous and slower struggling movements. We conclude that ascending interneurons are a major class of modulatory neurons producing inhibitory gating of cutaneous sensory pathways during swimming and struggling.
Alford,
Presynaptic GABAA and GABAB Receptor-mediated Phasic Modulation in Axons of Spinal Motor Interneurons.
1991, Pubmed
Alford,
Presynaptic GABAA and GABAB Receptor-mediated Phasic Modulation in Axons of Spinal Motor Interneurons.
1991,
Pubmed
Baev,
[Polarization of terminals of the primary afferents of the lumbar region of the spinal cord during fictitious locomotion].
1980,
Pubmed
Bayev,
Polarization of primary afferent terminals of lumbosacral cord elicited by the activity of spinal locomotor generator.
1982,
Pubmed
Bernhardt,
Identification of spinal neurons in the embryonic and larval zebrafish.
1990,
Pubmed
Buchanan,
Contributions of identifiable neurons and neuron classes to lamprey vertebrate neurobiology.
2001,
Pubmed
Büschges,
Sensory pathways and their modulation in the control of locomotion.
1998,
Pubmed
Clarke,
Sensory physiology, anatomy and immunohistochemistry of Rohon-Beard neurones in embryos of Xenopus laevis.
1984,
Pubmed
,
Xenbase
Clarke,
Interneurones in the Xenopus embryo spinal cord: sensory excitation and activity during swimming.
1984,
Pubmed
,
Xenbase
Dale,
Reciprocal inhibitory interneurones in the Xenopus embryo spinal cord.
1985,
Pubmed
,
Xenbase
Dale,
The Isolation and Identification of Spinal Neurons That Control Movement in the Xenopus Embryo.
1991,
Pubmed
,
Xenbase
El Manira,
Locomotor-related presynaptic modulation of primary afferents in the lamprey.
1997,
Pubmed
Gossard,
Phase-dependent modulation of dorsal root potentials evoked by peripheral nerve stimulation during fictive locomotion in the cat.
1990,
Pubmed
Harper,
Spinal cord neuron classes in embryos of the smooth newt Triturus vulgaris: a horseradish peroxidase and immunocytochemical study.
1993,
Pubmed
,
Xenbase
Jonas,
Corelease of two fast neurotransmitters at a central synapse.
1998,
Pubmed
Kirk,
Identified interneurons produce both primary afferent depolarization and presynaptic inhibition.
1984,
Pubmed
Lee,
Transcriptional networks regulating neuronal identity in the developing spinal cord.
2001,
Pubmed
Li,
Defining classes of spinal interneuron and their axonal projections in hatchling Xenopus laevis tadpoles.
2001,
Pubmed
,
Xenbase
Milner,
Cholinergic and GABAergic inputs drive patterned spontaneous motoneuron activity before target contact.
1999,
Pubmed
O'Brien,
Cotransmission of GABA and glycine to brain stem motoneurons.
1999,
Pubmed
Pearson,
Common principles of motor control in vertebrates and invertebrates.
1993,
Pubmed
Reith,
Pre- and postsynaptic modulation of spinal GABAergic neurotransmission by the neurosteroid, 5 beta-pregnan-3 alpha-ol-20-one.
1997,
Pubmed
,
Xenbase
Roberts,
Early functional organization of spinal neurons in developing lower vertebrates.
2000,
Pubmed
,
Xenbase
Roberts,
Characterization and Function of Spinal Excitatory Interneurons with Commissural Projections in Xenopus laevis embryos.
1990,
Pubmed
,
Xenbase
Roberts,
The neuroanatomy of an amphibian embryo spinal cord.
1982,
Pubmed
,
Xenbase
Roberts,
The early development of neurons with GABA immunoreactivity in the CNS of Xenopus laevis embryos.
1987,
Pubmed
,
Xenbase
Roberts,
Central circuits controlling locomotion in young frog tadpoles.
1998,
Pubmed
,
Xenbase
Roberts,
Synaptic potentials in motoneurons during fictive swimming in spinal Xenopus embryos.
1985,
Pubmed
,
Xenbase
Rudomin,
Presynaptic inhibition in the vertebrate spinal cord revisited.
1999,
Pubmed
Sillar,
Phase-dependent Modulation of a Cutaneous Sensory Pathway by Glycinergic Inhibition from the Locomotor Rhythm Generator in Xenopus Embryos.
1992,
Pubmed
,
Xenbase
Sillar,
The role of premotor interneurons in phase-dependent modulation of a cutaneous reflex during swimming in Xenopus laevis embryos.
1992,
Pubmed
,
Xenbase
Sillar,
A neuronal mechanism for sensory gating during locomotion in a vertebrate.
1988,
Pubmed
,
Xenbase
Sillar,
Control of frequency during swimming in Xenopus embryos: a study on interneuronal recruitment in a spinal rhythm generator.
1993,
Pubmed
,
Xenbase
Soffe,
Functional projection distances of spinal interneurons mediating reciprocal inhibition during swimming in Xenopus tadpoles.
2001,
Pubmed
,
Xenbase
Soffe,
Active and Passive Membrane Properties of Spinal Cord Neurons that Are Rhythmically Active during Swimming in Xenopus Embryos.
1990,
Pubmed
,
Xenbase
Soffe,
Tonic and phasic synaptic input to spinal cord motoneurons during fictive locomotion in frog embryos.
1982,
Pubmed
,
Xenbase
Soffe,
Activity of commissural interneurons in spinal cord of Xenopus embryos.
1984,
Pubmed
,
Xenbase
Soffe,
Two distinct rhythmic motor patterns are driven by common premotor and motor neurons in a simple vertebrate spinal cord.
1993,
Pubmed
,
Xenbase
Soffe,
Triggering and gating of motor responses by sensory stimulation: behavioural selection in Xenopus embryos.
1991,
Pubmed
,
Xenbase
Tunstall,
Longitudinal coordination of motor output during swimming in Xenopus embryos.
1991,
Pubmed
,
Xenbase
Tunstall,
A longitudinal gradient of synaptic drive in the spinal cord of Xenopus embryos and its role in co-ordination of swimming.
1994,
Pubmed
,
Xenbase
Wall,
GABAB receptors modulate glycinergic inhibition and spike threshold in Xenopus embryo spinal neurones.
1993,
Pubmed
,
Xenbase
Yoshida,
Axon projections of reciprocal inhibitory interneurons in the spinal cord of young Xenopus tadpoles and implications for the pattern of inhibition during swimming and struggling.
1998,
Pubmed
,
Xenbase
Zehr,
What functions do reflexes serve during human locomotion?
1999,
Pubmed
Zhao,
Asymmetries in sensory pathways from skin to motoneurons on each side of the body determine the direction of an avoidance response in hatchling Xenopus tadpoles.
1998,
Pubmed
,
Xenbase