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XB-ART-29134
Biochem Biophys Res Commun 1985 Jul 31;1302:854-66.
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The presence of two mitochondrial DNA topoisomerases in human acute leukemia cells.

Castora FJ , Lazarus GM , Kunes D .


Abstract
We have undertaken a study of DNA topoisomerases in mitochondria from human acute leukemia cells. Two activities have been detected in these organelles. One of the enzymes is presumably a type II topoisomerase, i.e., in ATP-dependent reactions it can catenate closed circular plasmid DNA, and decatenate closed circular kinetoplast DNA. A second topoisomerase is presumably a type I enzyme since, it can relax positive as well as negative supercoils in an ATP-independent reaction, it is unable to catenate plasmid DNA or decatenate kinetoplast DNA, and it is inhibited, rather than stimulated, by ATP.

PubMed ID: 2992488
Article link: Biochem Biophys Res Commun