Tong JJ , Sohn BC , Lam A , Walters DE , Vertel BM , Ebihara L .

R01 EY-10589 NEI NIH HHS , R01 EY010589 NEI NIH HHS

Addison, A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family. 2006, Pubmed

Addison, A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family. 2006, Pubmed
Arora, A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract. 2006, Pubmed , Xenbase
Arora, A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. 2008, Pubmed , Xenbase
Berthoud, Loss of function and impaired degradation of a cataract-associated mutant connexin50. 2003, Pubmed
Bukauskas, Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: properties of fast and slow gating mechanisms. 2002, Pubmed
Bukauskas, Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells. 1995, Pubmed
DeRosa, The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins. 2007, Pubmed , Xenbase
Dong, Role of the N-terminus in permeability of chicken connexin45.6 gap junctional channels. 2006, Pubmed
Ebihara, Effect of external magnesium and calcium on human connexin46 hemichannels. 2003, Pubmed , Xenbase
Ebihara, Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes. 1993, Pubmed , Xenbase
Günzel, The MgtC virulence factor of Salmonella enterica serovar Typhimurium activates Na(+),K(+)-ATPase. 2006, Pubmed , Xenbase
Hansen, The congenital "ant-egg" cataract phenotype is caused by a missense mutation in connexin46. 2006, Pubmed
Kronengold, The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates. 2012, Pubmed , Xenbase
Kronengold, Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels. 2003, Pubmed , Xenbase
Kwon, Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics. 2011, Pubmed , Xenbase
Maeda, Structure of the connexin 26 gap junction channel at 3.5 A resolution. 2009, Pubmed
Mathias, The lens circulation. 2007, Pubmed
Minogue, An aberrant sequence in a connexin46 mutant underlies congenital cataracts. 2005, Pubmed , Xenbase
Minogue, A mutant connexin50 with enhanced hemichannel function leads to cell death. 2009, Pubmed , Xenbase
Oh, Stoichiometry of transjunctional voltage-gating polarity reversal by a negative charge substitution in the amino terminus of a connexin32 chimera. 2000, Pubmed , Xenbase
Oh, Molecular determinants of electrical rectification of single channel conductance in gap junctions formed by connexins 26 and 32. 1999, Pubmed
Oh, Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannel. 2008, Pubmed , Xenbase
Pal, Connexin46 mutations linked to congenital cataract show loss of gap junction channel function. 2000, Pubmed , Xenbase
Pal, Molecular mechanism underlying a Cx50-linked congenital cataract. 1999, Pubmed , Xenbase
Pfahnl, Gating of cx46 gap junction hemichannels by calcium and voltage. 1999, Pubmed , Xenbase
Pfenniger, Mutations in connexin genes and disease. 2011, Pubmed
Purnick, Structure of the amino terminus of a gap junction protein. 2000, Pubmed , Xenbase
Schlingmann, Cataract-associated D3Y mutation of human connexin46 (hCx46) increases the dye coupling of gap junction channels and suppresses the voltage sensitivity of hemichannels. 2012, Pubmed , Xenbase
Skerrett, Aberrant gating, but a normal expression pattern, underlies the recessive phenotype of the deafness mutant Connexin26M34T. 2004, Pubmed , Xenbase
Srinivas, Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels. 2005, Pubmed , Xenbase
Thomas, Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50. 2008, Pubmed
Tong, Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels. 2006, Pubmed , Xenbase
Tong, Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. 2011, Pubmed , Xenbase
Trexler, The first extracellular loop domain is a major determinant of charge selectivity in connexin46 channels. 2000, Pubmed , Xenbase
Trexler, Voltage gating and permeation in a gap junction hemichannel. 1996, Pubmed , Xenbase
Verselis, Opposite voltage gating polarities of two closely related connexins. 1994, Pubmed , Xenbase
White, Is half of a lens gap junction channel better than none? Focus on "properties of two cataract-associated mutations located in the NH2 terminus of connexin 46". 2013, Pubmed
White, Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins. 1994, Pubmed , Xenbase
Willecke, Structural and functional diversity of connexin genes in the mouse and human genome. 2002, Pubmed
Xin, Aspartic acid residue D3 critically determines Cx50 gap junction channel transjunctional voltage-dependent gating and unitary conductance. 2012, Pubmed
Xu, Characterization of a mouse Cx50 mutation associated with the No2 mouse cataract. 1999, Pubmed , Xenbase
Zoidl, Gap junctions in inherited human disease. 2010, Pubmed