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XB-ART-29831
J Immunogenet 1984 Feb 01;111:97-101.
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Genetic limits of thymic immunosuppression of anti-hapten antibody production in Xenopus laevis laevis, the South African clawed toad.

Ruben LN , James HS , Clothier RH , Balls M .


Abstract
Thymic immunosuppression in adult Xenopus laevis laevis, the South African clawed toad, is antigen-dependent and antigen-specific, but it is not genetically restricted. In this report, we show that combination in vitro with a thymus from an immunized Xenopus laevis laevis can suppress antibody production to a hapten from spleen fragments, if the spleen fragments are derived from a subspecies of Xenopus laevis or a species of Xenopus which shares the same diploid chromosome number (2N = 36). Some aspects of the evolution of thymic immunosuppression are considered in the light of these results.

PubMed ID: 6707484

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