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Anat Embryol (Berl)
1993 Jun 01;1876:549-55. doi: 10.1007/bf00214433.
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Co-localization of serotonin and GABA in neurons of the Xenopus laevis retina.
Zhu BS
,
Straznicky C
.
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Serotonin-synthesizing neurons in the retina of Xenopus laevis have been identified using anti-phenylalanine hydroxylase (PH) antibody which recognizes tryptophan 5-hydroxylase, the rate-limiting enzyme for serotonin synthesis. Double-labelling experiments, using anti-PH antibody and anti-serotonin antibody/5,7-dihydroxytryptamine (5,7-DHT) uptake, have shown that some serotonin-like immunoreactive/5,7-DHT-labelled neurons exhibit PH-like immunoreactivity (PH-LI) (serotonin-synthesizing neurons), but the others do not (serotonin-accumulating neurons). In the present study, triple-labelling experiments were performed using 5,7-DHT uptake and antibodies raised against GABA and PH, to determine the possible co-localization of y-aminobutyric acid (GABA) in serotonin-synthesizing and/or -accumulating neurons in the Xenopus retina. All 5,7-DHT-labelled bipolar cells lacked PH-LI; all of them were immunoreactive to GABA. In contrast, all 5,7-DHT-labelled large amacrine cells exhibited PH-LI, but none of them expressed GABA-LI. Small amacrine cells labelled with 5,7-DHT but not PH-LI exhibited GABA-LI, whilst the small amacrine cells with PH-LI lacked GABA-LI. These observations indicate that GABA is co-localized in serotonin-accumulating amacrine and bipolar cells, whereas serotonin-synthesizing large and small amacrine cells do not contain GABA-LI.
Baker,
Melatonin localization in the eyes of larval Xenopus.
1971, Pubmed,
Xenbase
Baker,
Melatonin localization in the eyes of larval Xenopus.
1971,
Pubmed
,
Xenbase
Belin,
Immunohistochemical evidence for the presence of gamma-aminobutyric acid and serotonin in one nerve cell. A study on the raphe nuclei of the rat using antibodies to glutamate decarboxylase and serotonin.
1983,
Pubmed
Bruun,
Neurotransmitter localization in the skate retina.
1984,
Pubmed
Cahill,
Circadian regulation of melatonin in the retina of Xenopus laevis: limitation by serotonin availability.
1990,
Pubmed
,
Xenbase
Ehinger,
Indoleamine-accumulating neurons in the retina of rabbit, cat and goldfish.
1976,
Pubmed
Ehinger,
Neurotransmitter systems in the retina.
1982,
Pubmed
Gläsener,
Two populations of serotonin-immunoreactive neurons in the frog (Rana esculenta) retina.
1988,
Pubmed
Gábriel,
GABA-like immunoreactive neurons in the retina of Bufo marinus: evidence for the presence of GABA-containing ganglion cells.
1992,
Pubmed
Haan,
Identification of serotonergic neurons in human brain by a monoclonal antibody binding to all three aromatic amino acid hydroxylases.
1987,
Pubmed
Ma,
Transient expression of GABA immunoreactivity in the developing rat spinal cord.
1992,
Pubmed
Marc,
Serotonergic and serotonin-accumulating neurons in the goldfish retina.
1988,
Pubmed
Massey,
All indoleamine-accumulating cells in the rabbit retina contain GABA.
1992,
Pubmed
Millar,
Putative serotonergic bipolar and amacrine cells in the chicken retina.
1988,
Pubmed
Millhorn,
Extent of colocalization of serotonin and GABA in neurons of the ventral medulla oblongata in rat.
1988,
Pubmed
Mitchell,
Melatonin inhibits ACh release from rabbit retina.
1991,
Pubmed
Osborne,
Direct histochemical localisation of 5,7-dihydroxytryptamine and the uptake of serotonin by a subpopulation of GABA neurones in the rabbit retina.
1986,
Pubmed
Osborne,
Serotonin-containing neurones in vertebrate retinas.
1982,
Pubmed
Sandell,
A system of indoleamine-accumulating neurons in the rabbit retina.
1986,
Pubmed
Schütte,
Serotonin-like immunoreactivity in the retina of the clawed frog Xenopus laevis.
1990,
Pubmed
,
Xenbase
Vaney,
Morphological identification of serotonin-accumulating neurons in the living retina.
1986,
Pubmed
Watt,
A double-label study demonstrating that all serotonin-like immunoreactive amacrine cells in the larval tiger salamander retina express GABA-like immunoreactivity.
1992,
Pubmed
Weiler,
Morphological and pharmacological analysis of putative serotonergic bipolar and amacrine cells in the retina of a turtle, Pseudemys scripta elegans.
1985,
Pubmed
Wiechmann,
HIOMT-like immunoreactivity in the vertebrate retina: a species comparison.
1989,
Pubmed
,
Xenbase
Wilhelm,
Immunocytochemical identification of serotonin-synthesizing neurons in the vertebrate retina: a comparative study.
1993,
Pubmed
Wässle,
Morphological and immunocytochemical identification of indoleamine-accumulating neurons in the cat retina.
1987,
Pubmed
Wässle,
Dopaminergic and indoleamine-accumulating amacrine cells express GABA-like immunoreactivity in the cat retina.
1988,
Pubmed
Yang,
Localization of serotoninlike-immunoreactive amacrine cells in the larval tiger salamander retina.
1989,
Pubmed
Zhu,
Morphology and distribution of serotonin-like immunoreactive amacrine cells in the retina of Bufo marinus.
1990,
Pubmed
Zhu,
Serotonin synthesis and accumulation by neurons of the anuran retina.
1992,
Pubmed
,
Xenbase
Zhu,
Large serotonin-like immunoreactive amacrine cells in the retina of developing Xenopus laevis.
1992,
Pubmed
,
Xenbase
