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Genes Dev
2003 Dec 15;1724:3023-8. doi: 10.1101/gad.1153603.
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Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.
Pera EM
,
Ikeda A
,
Eivers E
,
De Robertis EM
.
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How do very diverse signaling pathways induce neural differentiation in Xenopus? Anti-BMP (Chordin), FGF8, and IGF2 signals are integrated in the embryo via the regulation of Smad1 phosphorylation. Neural induction results from the combined inhibition of BMP receptor serine/threonine kinases and activation of receptor tyrosine kinases that signal through MAPK and phosphorylate Smad1 in the linker region, further inhibiting Smad1 transcriptional activity. This hard-wired molecular mechanism at the level of the Smad1 transcription factor may help explain the opposing activities of IGF, FGF, and BMP signals not only in neural induction, but also in other aspects of vertebrate development.
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14701872
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Blume-Jensen,
Oncogenic kinase signalling.
2001,
Pubmed
Chesnel,
Comparative effects of insulin on the activation of the Raf/Mos-dependent MAP kinase cascade in vitellogenic versus postvitellogenic Xenopus oocytes.
1997,
Pubmed
,
Xenbase
Christen,
FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus.
1997,
Pubmed
,
Xenbase
Collavin,
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm.
2003,
Pubmed
,
Xenbase
Cooke,
Gastrulation and larval pattern in Xenopus after blastocoelic injection of a Xenopus-derived inducing factor: experiments testing models for the normal organization of mesoderm.
1989,
Pubmed
,
Xenbase
De Robertis,
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
2000,
Pubmed
,
Xenbase
Grimm,
Nuclear exclusion of Smad2 is a mechanism leading to loss of competence.
2002,
Pubmed
,
Xenbase
Hardcastle,
FGF-8 stimulates neuronal differentiation through FGFR-4a and interferes with mesoderm induction in Xenopus embryos.
2000,
Pubmed
,
Xenbase
Harland,
Neural induction.
2000,
Pubmed
,
Xenbase
Hongo,
FGF signaling and the anterior neural induction in Xenopus.
1999,
Pubmed
,
Xenbase
Kretzschmar,
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.
1999,
Pubmed
Kretzschmar,
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
1997,
Pubmed
Lamb,
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern.
1995,
Pubmed
,
Xenbase
Massague,
Integration of Smad and MAPK pathways: a link and a linker revisited.
2003,
Pubmed
Massagué,
Controlling TGF-beta signaling.
2000,
Pubmed
Nguyen,
Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway.
2000,
Pubmed
Niswander,
FGF-4 and BMP-2 have opposite effects on limb growth.
1993,
Pubmed
Pera,
Neural and head induction by insulin-like growth factor signals.
2001,
Pubmed
,
Xenbase
Richard-Parpaillon,
The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus.
2002,
Pubmed
,
Xenbase
Sater,
Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification.
2003,
Pubmed
,
Xenbase
Schohl,
Beta-catenin, MAPK and Smad signaling during early Xenopus development.
2002,
Pubmed
,
Xenbase
Stern,
Induction and initial patterning of the nervous system - the chick embryo enters the scene.
2002,
Pubmed
,
Xenbase
Streit,
Initiation of neural induction by FGF signalling before gastrulation.
2000,
Pubmed
Streit,
A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation.
1995,
Pubmed
Streit,
Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2.
1997,
Pubmed
,
Xenbase
Thesleff,
The role of growth factors in tooth development.
2002,
Pubmed
Warren,
The BMP antagonist noggin regulates cranial suture fusion.
2003,
Pubmed
Weaver,
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.
2000,
Pubmed
Weinstein,
Neural induction.
1999,
Pubmed
,
Xenbase
Wilson,
An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo.
2000,
Pubmed
,
Xenbase
Wilson,
Neural induction: toward a unifying mechanism.
2001,
Pubmed
