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XB-ART-8084
Dev Cell 2001 Nov 01;15:655-65. doi: 10.1016/s1534-5807(01)00069-7.
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Neural and head induction by insulin-like growth factor signals.

Pera EM , Wessely O , Li SY , De Robertis EM .


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Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus.

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Species referenced: Xenopus laevis
Genes referenced: ag1 chrd hoxd1 igfbp5 ins otx2 rax six3 tbx2


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