Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
1987 Dec 01;612:3809-18. doi: 10.1002/j.1460-2075.1987.tb02717.x.
Show Gene links
Show Anatomy links
A new lamin in Xenopus somatic tissues displays strong homology to human lamin A.
Wolin SL
,
Krohne G
,
Kirschner MW
.
???displayArticle.abstract???
The nuclear lamina of vertebrates is composed of several major polypeptides that range in mol. wt from 60 to 80 kd. In mammals, the three major lamin proteins are designated A, B and C. Two major lamins have been described in Xenopus somatic tissues; two other lamins are expressed primarily in germ cells. We have analysed a cDNA clone encoding a Xenopus lamin that is highly homologous to human lamins A and C. The predicted protein has the carboxy-terminal domain characteristic of human lamin A and is thus a lamin A homologue. Surprisingly, the lamin encoded by the cDNA clone is not one of the known Xenopus lamins. The encoded protein is distinct in size from the oocyte lamin LIII and the two somatic lamins LI and LII. Monoclonal antibodies specific for LII, LIII and LIV (the lamin of male germ cells) do not recognize the protein encoded by the cDNA clone; conversely, a polyclonal antibody against the encoded protein does not recognize any of the known Xenopus lamins. This lamin is expressed late in embryonic development, and is present in all adult somatic cells examined, except erythrocytes. Thus frogs and mammals are similar in having three major somatic lamins that fall into distinct structural classes.
Aebi,
The nuclear lamina is a meshwork of intermediate-type filaments.
, Pubmed,
Xenbase
Aebi,
The nuclear lamina is a meshwork of intermediate-type filaments.
,
Pubmed
,
Xenbase
Benavente,
Cell type-specific expression of nuclear lamina proteins during development of Xenopus laevis.
1985,
Pubmed
,
Xenbase
Benavente,
Change of karyoskeleton during spermatogenesis of Xenopus: expression of lamin LIV, a nuclear lamina protein specific for the male germ line.
1985,
Pubmed
,
Xenbase
Benton,
Screening lambdagt recombinant clones by hybridization to single plaques in situ.
1977,
Pubmed
Burke,
A cell free system to study reassembly of the nuclear envelope at the end of mitosis.
1986,
Pubmed
Cortese,
Cloning of nematode tRNA genes and their expression in the frog oocyte.
1978,
Pubmed
,
Xenbase
Dwyer,
A modified procedure for the isolation of a pore complex-lamina fraction from rat liver nuclei.
1976,
Pubmed
Erickson,
Cell-free translation of messenger RNA in a wheat germ system.
1983,
Pubmed
Fawcett,
On the occurrence of a fibrous lamina on the inner aspect of the nuclear envelope in certain cells of vertebrates.
1966,
Pubmed
Feinberg,
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
1983,
Pubmed
Fisher,
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.
1986,
Pubmed
Franke,
The nuclear envelope and the architecture of the nuclear periphery.
1981,
Pubmed
Fuchs,
Unraveling the structure of the intermediate filaments.
1983,
Pubmed
Gerace,
Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution.
1978,
Pubmed
Gerace,
The nuclear envelope lamina is reversibly depolymerized during mitosis.
1980,
Pubmed
Granger,
Synemin and vimentin are components of intermediate filaments in avian erythrocytes.
1982,
Pubmed
Guilly,
Autoantibodies to nuclear lamin B in a patient with thrombopenia.
1987,
Pubmed
Hoffmann,
Amino acid sequence microheterogeneities of basic (type II) cytokeratins of Xenopus laevis epidermis and evolutionary conservativity of helical and non-helical domains.
1985,
Pubmed
,
Xenbase
Jonas,
Epidermal keratin gene expressed in embryos of Xenopus laevis.
1985,
Pubmed
,
Xenbase
Krieg,
Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs.
1985,
Pubmed
,
Xenbase
Krohne,
The major polypeptides of the nuclear pore complex.
1978,
Pubmed
,
Xenbase
Krohne,
Cell type-specific differences in protein composition of nuclear pore complex-lamina structures in oocytes and erythrocytes of Xenopus laevis.
1981,
Pubmed
,
Xenbase
Krohne,
Proteins of pore complex--lamina structures from nuclei and nuclear membranes.
1983,
Pubmed
,
Xenbase
Krohne,
The nuclear lamins. A multigene family of proteins in evolution and differentiation.
1986,
Pubmed
,
Xenbase
Krohne,
Nuclear lamin LI of Xenopus laevis: cDNA cloning, amino acid sequence and binding specificity of a member of the lamin B subfamily.
1987,
Pubmed
,
Xenbase
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Lebkowski,
Evidence for two levels of DNA folding in histone-depleted HeLa interphase nuclei.
1982,
Pubmed
Lehner,
The nuclear lamin protein family in higher vertebrates. Identification of quantitatively minor lamin proteins by monoclonal antibodies.
1986,
Pubmed
Lehner,
Differential expression of nuclear lamin proteins during chicken development.
1987,
Pubmed
,
Xenbase
McKeon,
Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma.
1983,
Pubmed
McKeon,
Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins.
,
Pubmed
Miake-Lye,
Maturation-promoting factor induces nuclear envelope breakdown in cycloheximide-arrested embryos of Xenopus laevis.
1983,
Pubmed
,
Xenbase
Mimori,
Autoantibodies to the U2 small nuclear ribonucleoprotein in a patient with scleroderma-polymyositis overlap syndrome.
1984,
Pubmed
Miyatani,
Stage-specific keratins in Xenopus laevis embryos and tadpoles: the XK81 gene family.
1986,
Pubmed
,
Xenbase
Moll,
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.
1982,
Pubmed
Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase
Norrander,
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.
1983,
Pubmed
Rebagliati,
Identification and cloning of localized maternal RNAs from Xenopus eggs.
1985,
Pubmed
,
Xenbase
Rigby,
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
1977,
Pubmed
Ruderman,
Modulations of histone messenger RNA during the early development of Xenopus laevis.
1979,
Pubmed
,
Xenbase
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Schatten,
Nuclear lamins and peripheral nuclear antigens during fertilization and embryogenesis in mice and sea urchins.
1985,
Pubmed
Stick,
Changes in the nuclear lamina composition during early development of Xenopus laevis.
1985,
Pubmed
,
Xenbase
Thomas,
An octamer of histones in chromatin and free in solution.
1975,
Pubmed
Turner,
H3 and H4 histone cDNA sequences from Xenopus: a sequence comparison of H4 genes.
1982,
Pubmed
,
Xenbase
