Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-23242
Neuroreport 1992 Nov 01;311:1013-6.
Show Gene links Show Anatomy links

3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.

Ito I , Kohda A , Tanabe S , Hirose E , Hayashi M , Mitsunaga S , Sugiyama H .


???displayArticle.abstract???
An amino acid, 3,5-dihydroxyphenylglycine (DHPG) induced current responses in Xenopus oocytes expressing a metabotropic glutamate receptor clone mGluR1. Apparent EC50 of DHPG for mGluR1 was slightly lower than that of (+-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD). DHPG responses were partially inhibited by 2-amino-3-phosphonopropionic acid (AP-3). DHPG had no effect on ionotropic glutamate receptors whose expression was induced in the oocytes following injection of poly(A)+ mRNA of rat brains. In hippocampal slices, DHPG produced slow excitation of pyramidal cells, resulting from a depression of Ca(2+)-dependent K+ current and a voltage-dependent K+ current. These results indicate that DHPG is a specific and potent agonist of mGluRs.

???displayArticle.pubmedLink??? 1362358



Species referenced: Xenopus
Genes referenced: grm1