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XB-ART-26694
Nature 1989 Jun 22;3396226:597-603. doi: 10.1038/339597a0.
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Structural parts involved in activation and inactivation of the sodium channel.

Stühmer W , Conti F , Suzuki H , Wang XD , Noda M , Yahagi N , Kubo H , Numa S .


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Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.

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