Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-28223
Science 1987 Mar 20;2354795:1489-92.
Show Gene links Show Anatomy links

Molecular cloning and expression of a human B-cell growth factor gene in Escherichia coli.

Sharma S , Mehta S , Morgan J , Maizel A .


Abstract
A human B-cell growth factor (BCGF) (12 kilodaltons) supports the clonal proliferation of B lymphocytes. A clone was isolated that contained the proper structural sequence to encode biologically active, 12-kilodalton BCGF in Escherichia coli and to hybridize to a specific messenger RNA, identified by in vitro translation in Xenopus laevis oocytes. A relatively hydrophobic region of 18 amino acids was found at the amino terminal of the 124-amino acid-long polypeptide. The carboxyl terminal is composed of at least 32 amino acids that are derived from nucleotide sequences bearing significant homology to the Alu repeat family.

PubMed ID: 3547651
Article link: Science
Grant support: [+]


References :
Zietkiewicz, Phylogenetic analysis of a reported complementary DNA sequence. 1994, Pubmed