Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-45710
Virology 2012 Oct 25;4322:435-43. doi: 10.1016/j.virol.2012.07.001.
Show Gene links Show Anatomy links

Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs.

De Jesús Andino F , Chen G , Li Z , Grayfer L , Robert J .


???displayArticle.abstract???
Xenopus laevis adults mount effective immune responses to ranavirus Frog Virus 3 (FV3) infections and clear the pathogen within 2-3 weeks. In contrast, most tadpoles cannot clear FV3 and succumb to infections within a month. While larval susceptibility has been attributed to ineffective adaptive immunity, the contribution of innate immune components has not been addressed. Accordingly, we performed a comprehensive gene expression analysis on FV3-infected tadpoles and adults. In comparison to adults, leukocytes and tissues of infected tadpoles exhibited modest (10-100 time lower than adult) and delayed (3 day later than adult) increase in expression of inflammation-associated (TNF-α, IL-1β and IFN-γ) and antiviral (Mx1) genes. In contrast, these genes were readily and robustly upregulated in tadpoles upon bacterial stimulation. Furthermore, greater proportions of larval than adult PLs were infected by FV3. Our study suggests that tadpole susceptibility to FV3 infection is partially due to poor virus-elicited innate immune responses.

???displayArticle.pubmedLink??? 22819836
???displayArticle.pmcLink??? PMC3574294
???displayArticle.link??? Virology
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: mx1 tnf

References [+] :
Bartee, Tumor necrosis factor and interferon: cytokines in harmony. 2008, Pubmed