Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Functional analysis of tight junction organization.
DiBona DR
.
Abstract
The functional basis of tight junction design has been examined from the point of view that this rate-limiting barrier to paracellular transport is a multicompartment system. Review of the osmotic sensitivity of these structures points to the need for this sort of analysis for meaningful correlation of structure and function under a range of conditions. A similar conclusion is drawn with respect to results from voltage-clamping protocols where reversal of spontaneous transmural potential difference elicits parallel changes in both structure and function in much the same way as does reversal of naturally occurring osmotic gradients. In each case, it becomes necessary to regard the junction as a functionally polarized structure to account for observations of its rectifying properties. Lastly, the details of experimentally-induced junction deformation are examined in light of current theories of its organization; arguments are presented in favor of the view that the primary components of intramembranous organization (as viewed with freeze-fracture techniques) are lipidic rather than proteinaceous.
Bobrycki,
Structural responses to voltage-clamping in the toad urinary bladder. I. The principal role of granular cells in the active transport of sodium.
1981, Pubmed
Bobrycki,
Structural responses to voltage-clamping in the toad urinary bladder. I. The principal role of granular cells in the active transport of sodium.
1981,
Pubmed
Cereijido,
Occluding junctions and paracellular pathways studied in monolayers of MDCK cells.
1983,
Pubmed
Cereijido,
Occluding junctions in a cultured transporting epithelium: structural and functional heterogeneity.
1980,
Pubmed
Civan,
Pathways for movement of ions and water across toad urinary bladder. III. Physiologic significance of the paracellular pathway.
1978,
Pubmed
Civan,
Pathways for movement of ions and water across toad urinary bladder. II. Site and mode of action of vasopressin.
1974,
Pubmed
,
Xenbase
Claude,
Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia.
1973,
Pubmed
Claude,
Morphological factors influencing transepithelial permeability: a model for the resistance of the zonula occludens.
1978,
Pubmed
DiBona,
Direct visualization of epithelial morphology in the living amphibian urinary bladder.
1978,
Pubmed
DiBona,
Pathways for movement of ions and water across toad urinary bladder. I. Anatomic site of transepithelial shunt pathways.
1973,
Pubmed
DiBona,
A study of intercellular spaces in the rabbit jejunum during acute volume expansion and after treatment with cholera toxin.
1974,
Pubmed
DiBona,
Passive intercellular pathway in amphibian epithelia.
1972,
Pubmed
Duffey,
Regulation of epithelial tight junction permeability by cyclic AMP.
1981,
Pubmed
FARQUHAR,
Junctional complexes in various epithelia.
1963,
Pubmed
Friend,
Variations in tight and gap junctions in mammalian tissues.
1972,
Pubmed
Frizzell,
Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differences.
1972,
Pubmed
Frömter,
Route of passive ion permeation in epithelia.
1972,
Pubmed
Gilula,
The Sertoli cell occluding junctions and gap junctions in mature and developing mammalian testis.
1976,
Pubmed
González-Mariscal,
Effect of temperature on the occluding junctions of monolayers of epithelioid cells (MDCK).
1984,
Pubmed
Kachar,
Evidence for the lipidic nature of tight junction strands.
1982,
Pubmed
Kachar,
Rapid massive assembly of tight junction strands.
1981,
Pubmed
Lane,
Definitive evidence for the existence of tight junctions in invertebrates.
1980,
Pubmed
Lord,
Role of the septate junction in the regulation of paracellular transepithelial flow.
1976,
Pubmed
Madara,
Increases in guinea pig small intestinal transepithelial resistance induced by osmotic loads are accompanied by rapid alterations in absorptive-cell tight-junction structure.
1983,
Pubmed
Mandel,
Response of the frog skin to steady-state voltage clamping. I. The shunt pathway.
1972,
Pubmed
Miller,
Do 'lipidic particles' represent intermembrane attachment sites?
1980,
Pubmed
Patlak,
The flow of solute and solvent across a two-membrane system.
1963,
Pubmed
Reuss,
Effects of changes in the composition of the mucosal solution on the electrical properties of the toad urinary bladder epithelium.
1975,
Pubmed
Sardet,
The surface epithelium of teleostean fish gills. Cellular and junctional adaptations of the chloride cell in relation to salt adaptation.
1979,
Pubmed
Schneeberger,
Tight junctions. Their structure, composition, and function.
1984,
Pubmed
Schultz,
The role of paracellular pathways in isotonic fluid transport.
1977,
Pubmed
Smulders,
The effect of osmotically induced water flows on the permeability and ultrastructure of the rabbit gallbladder.
1972,
Pubmed
Staehelin,
Freeze-etch appearance of the tight junctions in the epithelium of small and large intestine of mice.
1969,
Pubmed
Stevenson,
Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterization.
1984,
Pubmed
Urakabe,
Effect of hypertonicity on permeability properties of the toad bladder.
1970,
Pubmed
van Deurs,
Effects of glutaraldehyde fixation on the structure of tight junctions: a quantitative freeze-fracture analysis.
1979,
Pubmed
Wade,
Fracture faces of osmotically disrupted zonulae occludentes.
1974,
Pubmed
Wade,
Effect of osmotic gradients on intercellular junctions of the toad bladder.
1973,
Pubmed
Wigglesworth,
The role of the epidermal cells in moulding the surface pattern of the cuticle in Rhodnius (Hemiptera).
1973,
Pubmed