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XB-ART-4771
Trends Cell Biol 2003 Sep 01;139:451-4. doi: 10.1016/s0962-8924(03)00173-9.
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Cell polarity pathways converge and extend to regulate neural tube closure.

Zohn IE , Chesnutt CR , Niswander L .


Abstract
Neural tube defects, such as spinabifida, craniorachischisis and anencephaly, are some of the most common birth defects in humans. Recent studies in mouse model systems suggest that craniorachischisis is associated with mutations in genes that regulate cell polarity. Using Xenopus as a model system, Wallingford and Harland have now shed light on the mechanism by which these pathways affect neural tube closure.

PubMed ID: 12946622
Article link: Trends Cell Biol