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XB-ART-11294
FEBS Lett 2000 Mar 24;4702:135-8.
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A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides.

Vais H , Atkinson S , Eldursi N , Devonshire AL , Williamson MS , Usherwood PN .


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Two amino acid substitutions in a housefly sodium channel, L1014F in domain IIS6 and M918T in the IIS4-S5 linker, have been identified in kdr and super-kdr pyrethroid-resistant phenotypes, respectively. Unlike their native insect counterparts, mammalian sodium channels are only weakly sensitive to pyrethroids. Do the sodium channels of mammal and pyrethroid-resistant housefly share similar structural characteristics that account for their low pyrethroid sensitivities? We report here that substitution of isoleucine for methionine at position 874 (equivalent to the super-kdr site 918 in the housefly) in the rat IIA alpha-subunit causes a 100-fold increase in sensitivity.

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Species referenced: Xenopus laevis
Genes referenced: kdr