Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Pestic Biochem Physiol
2010 Jun 01;972:78-86. doi: 10.1016/j.pestbp.2009.06.010.
Show Gene links
Show Anatomy links
State-Dependent Modification of Voltage-Gated Sodium Channels by Pyrethroids.
Soderlund DM
.
???displayArticle.abstract???
Pyrethroids disrupt nerve function by altering the rapid kinetic transitions between conducting and nonconducting states of voltage-gated sodium channels that underlie the generation of nerve action potentials. Recent studies of pyrethroid action on cloned insect and mammalian sodium channel isoforms expressed in Xenopus laevis oocytes show that in some cases pyrethroid modification is either absolutely dependent on or significantly enhanced by repeated channel activation. These use-dependent effects have been interpreted as evidence of preferential binding of at least some pyrethroids to the open, rather than resting, state of the sodium channel. This paper reviews the evidence for state-dependent modification of insect and mammalian sodium channels expressed in oocytes by pyrethroids and considers the implications of state-dependent effects for understanding the molecular mechanism of pyrethroid action and the development and testing of models of the pyrethroid receptor.
Bezanilla,
Voltage-gated ion channels.
2005, Pubmed
Bezanilla,
Voltage-gated ion channels.
2005,
Pubmed
Brown,
Modulation of nerve membrane sodium channel activation by deltamethrin.
1992,
Pubmed
Candenas,
Molecular diversity of voltage-gated sodium channel alpha and beta subunit mRNAs in human tissues.
2006,
Pubmed
Catterall,
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
2005,
Pubmed
Catterall,
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
2000,
Pubmed
Chen,
Cloning, distribution and functional analysis of the type III sodium channel from human brain.
2000,
Pubmed
Choi,
Cyclosporin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes.
2004,
Pubmed
,
Xenbase
Choi,
Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes.
2006,
Pubmed
,
Xenbase
Derst,
Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE.
2006,
Pubmed
,
Xenbase
Felts,
Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.
1997,
Pubmed
Feng,
Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function.
1995,
Pubmed
,
Xenbase
Ginsburg,
Differential sensitivity of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels to the insecticide allethrin in rat dorsal root ganglion neurons.
1993,
Pubmed
Goldin,
Mechanisms of sodium channel inactivation.
2003,
Pubmed
HODGKIN,
A quantitative description of membrane current and its application to conduction and excitation in nerve.
1952,
Pubmed
Hille,
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.
1977,
Pubmed
Lee,
Cloning and functional characterization of a putative sodium channel auxiliary subunit gene from the house fly (Musca domestica).
2000,
Pubmed
,
Xenbase
Lombet,
Interaction of insecticides of the pyrethroid family with specific binding sites on the voltage-dependent sodium channel from mammalian brain.
1988,
Pubmed
Loughney,
Molecular analysis of the para locus, a sodium channel gene in Drosophila.
1989,
Pubmed
Meacham,
Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids.
2008,
Pubmed
,
Xenbase
Meadows,
Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes.
2005,
Pubmed
Narahashi,
Neuronal ion channels as the target sites of insecticides.
1996,
Pubmed
Narahashi,
Nerve membrane Na+ channels as targets of insecticides.
1992,
Pubmed
O'Reilly,
Modelling insecticide-binding sites in the voltage-gated sodium channel.
2006,
Pubmed
Salgado,
Immobilization of sodium channel gating charge in crayfish giant axons by the insecticide fenvalerate.
1993,
Pubmed
Shah,
beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain.
2000,
Pubmed
,
Xenbase
Smith,
Actions of the pyrethroid insecticides cismethrin and cypermethrin on house fly Vssc1 sodium channels expressed in Xenopus oocytes.
1998,
Pubmed
,
Xenbase
Smith,
Action of the pyrethroid insecticide cypermethrin on rat brain IIa sodium channels expressed in xenopus oocytes.
1998,
Pubmed
,
Xenbase
Smith,
The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyrethroids.
1997,
Pubmed
,
Xenbase
Soderlun,
Point mutations in homology domain II modify the sensitivity of rat Nav1.8 sodium channels to the pyrethroid insecticide cismethrin.
2001,
Pubmed
,
Xenbase
Soderlund,
Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment.
2002,
Pubmed
SupYoon,
Three mutations identified in the voltage-sensitive sodium channel alpha-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes.
2008,
Pubmed
,
Xenbase
Tabarean,
Kinetics of modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by tetramethrin and deltamethrin.
2001,
Pubmed
Tan,
Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin.
2002,
Pubmed
,
Xenbase
Tan,
Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin.
2009,
Pubmed
,
Xenbase
Thimmapaya,
Distribution and functional characterization of human Nav1.3 splice variants.
2005,
Pubmed
,
Xenbase
Ulbricht,
Sodium channel inactivation: molecular determinants and modulation.
2005,
Pubmed
Usherwood,
Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT.
2007,
Pubmed
,
Xenbase
Vais,
Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.
2003,
Pubmed
,
Xenbase
Vais,
Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations.
2000,
Pubmed
,
Xenbase
Vais,
Functional analysis of a rat sodium channel carrying a mutation for insect knock-down resistance (kdr) to pyrethroids.
1997,
Pubmed
,
Xenbase
Vais,
A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides.
2000,
Pubmed
,
Xenbase
Wang,
Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.
2004,
Pubmed
Warmke,
Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology.
1997,
Pubmed
,
Xenbase
Yamaoka,
Na+ channel pharmacology and molecular mechanisms of gating.
2006,
Pubmed
Yu,
Overview of the voltage-gated sodium channel family.
2003,
Pubmed
Zhao,
Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel.
2000,
Pubmed
,
Xenbase
de Weille,
Interactions of pyrethroids and octylguanidine with sodium channels of squid giant axons.
1988,
Pubmed
