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XB-ART-27249
J Biol Chem 1988 Oct 15;26329:14614-6.
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mRNA-induced expression of the cardiac Na+-Ca2+ exchanger in Xenopus oocytes.

Sigel E , Baur R , Porzig H , Reuter H .


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Xenopus oocytes were injected with total mRNA isolated from hearts of 1-day-old chicks. After 5 days of incubation the follicular cell layers were removed and the oocytes were loaded with Na+ by incubation in hypertonic EGTA solution at 37 degrees C. The Na+-loaded oocytes accumulated 45Ca2+ from a Na+-free medium at a 3-18-fold higher rate than noninjected oocytes or oocytes injected with control solution containing no mRNA. Oocytes not subjected to the Na+-loading procedure showed no mRNA-dependent 45Ca2+ uptake. Size fractionation of the mRNA using sucrose density gradient centrifugation under denaturing conditions led to the identification of a 25 S fraction competent for induction of the Na+-Ca2+ exchange system.

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???displayArticle.link??? J Biol Chem