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XB-ART-16369
FEBS Lett 1997 Jun 09;4092:277-82.
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Molecular cloning and expression of a bovine endothelial inward rectifier potassium channel.

Forsyth SE , Hoger A , Hoger JH .


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A 5.1 kb cDNA encoding an inward rectifier K+ channel (BIK) was isolated from a bovine aortic endothelial cell library. The cDNA codes for a 427-amino-acid protein with two putative transmembrane regions. Sequence analysis reveals that BIK is a member of the Kir2.1 family of inward rectifier K+ channels. Expression in Xenopus oocytes showed that BIK is a K+-specific strong inward rectifier channel that is sensitive to extracellular Ba2+, Cs+, and a variety of anti-arrhythmic agents. Northern analysis revealed that endothelial cells express a 5.5 kb BIK mRNA that is sensitive to shear stress.

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Species referenced: Xenopus
Genes referenced: kcnj2