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Cell 2004 Nov 24;1195:641-51. doi: 10.1016/j.cell.2004.10.029.
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Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.

Barnard DC , Ryan K , Manley JL , Richter JD .

Cytoplasmic polyadenylation-induced mRNA translation is a hallmark of early animal development. In Xenopus oocytes, where the molecular mechanism has been defined, the core factors that control this process include CPEB, an RNA binding protein whose association with the CPE specifies which mRNAs undergo polyadenylation; CPSF, a multifactor complex that interacts with the near-ubiquitous polyadenylation hexanucleotide AAUAAA; and maskin, a CPEB and eIF4E binding protein whose regulation of initiation is governed by poly(A) tail length. Here, we define two new factors that are essential for polyadenylation. The first is symplekin, a CPEB and CPSF binding protein that serves as a scaffold upon which regulatory factors are assembled. The second is xGLD-2, an unusual poly(A) polymerase that is anchored to CPEB and CPSF even before polyadenylation begins. The identification of these factors has broad implications for biological process that employ polyadenylation-regulated translation, such as gametogenesis, cell cycle progression, and synaptic plasticity.

PubMed ID: 15550246
Article link: Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cpeb1 eif4e mos myc sympk tacc3 tent2

Article Images: [+] show captions