Suzuki M , Igawa T , Suzuki N , Ogino H , Ochi H .

Figure 1. : (A–C) Representative images of spontaneous neoplasia in Xenopus tropicalis. (A) External morphology of the neoplasia. The arrow indicates the black stone-like nodules, and the arrowhead indicates the white-red nodules. The upper right panel depicts the frog for which the neoplasia was resected. (B) The layered structure in the black stone-like nodules. Hematoxylin–eosin (HE) staining of a histological section of the black stone-like nodule. The white arrow indicates the layered structure. Scale bar indicates 50 μm. (C) The cyst-like structures and blood vessels in the white-red nodule. HE staining of a section of the white-red nodule. The white arrowheads indicate cyst-like structures and the black arrows blood vessels. Scale bar indicates 50 μm. (D) A table showing the number of frogs with neoplasia in each colony. Regarding colony names, the first 2–3 alphabets indicate the strain names, the following Greek numbers indicate the inbred generations, and the Arabic numbers (with case numbers) indicate the colony identifiers. Most of the frogs maintained at the stock center were shipped to users as animal resources, and the remaining frogs as of May 28, 2020, were subjected to this analysis. (E) A table showing the size of neoplasia; the size was determined by measuring diameters at large and small ends, and the height above the skin surface for each neoplasia.

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